Structure Features and Anti-Gastric Ulcer Effects of Inulin-Type Fructan CP-A from the Roots of Codonopsis pilosula (Franch.) Nannf.
1
School of Pharmaceutical Science, Shanxi Medical University, No. 56 Xinjian South Road, Taiyuan 030001, China
2
School of Basic Medical Science, Shanxi Medical University, No. 56 Xinjian South Road, Taiyuan 030001, China
*
Author to whom correspondence should be addressed.
Molecules 2017, 22(12), 2258; https://doi.org/10.3390/molecules22122258
Received: 23 October 2017 / Revised: 5 December 2017 / Accepted: 12 December 2017 / Published: 18 December 2017
Radix Codonopsis has been used in traditional Chinese medicine for strengthening the immune system, improving poor gastrointestinal function, treating gastric ulcers and chronic gastritis and so on. In the present study, an inulin-type fructan CP-A was obtained from the roots of Codonopsis pilosula (Franch.) Nannf. and its structure was confirmed by MS and NMR as (2 → 1) linked-β-d-fructofuranose. The protective effects of CP-A against ethanol-induced acute gastric ulcer in rats were intensively investigated. A Lacy assay demonstrated that CP-A-treated group (50 mg/kg) showed the gastric damage level 1, which was similar to the positive control group, while the model group exhibited the gastric damage level 3. The Guth assay demonstrated that the mucosa ulcer index for CP-A groups at the doses of 50 mg/kg and 25 mg/kg significantly decreased compared with that in the model group (p < 0.05). Meanwhile, CP-A significantly increased the activities of SOD and GSH-Px, and decreased the contents of MDA and NO, and the activity of MPO in gastric tissue in a dose-dependent manner (p < 0.05). The present research reported for the first time that inulin-type fructan CP-A were likely the potential component in Radix Codonopsis for treatment of acute gastric ulcers.
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Keywords:
Codonopsis pilosula (Franch.) Nannf.; inulin-type fructan; gastric ulcer; structure determination; carbohydrate
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MDPI and ACS Style
Li, J.; Wang, T.; Zhu, Z.; Yang, F.; Cao, L.; Gao, J. Structure Features and Anti-Gastric Ulcer Effects of Inulin-Type Fructan CP-A from the Roots of Codonopsis pilosula (Franch.) Nannf.. Molecules 2017, 22, 2258.
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