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Molecules 2017, 22(12), 2156;

Bioactive Steroids and Saponins of the Genus Trillium

Department of Pharmacy, Shaheed Benazir Bhutto University, Sheringal, Dir 18000, Pakistan
Department of Pharmacy, University of Peshawar, Peshawar 25120, Pakistan
Department of Pharmacy, Sarhad University of Science and Information Technology, Peshawar 25120, Pakistan
Department of Agricultural and Environmental Sciences, Milan State University, 20133 Milan, Italy
Authors to whom correspondence should be addressed.
Received: 17 October 2017 / Revised: 19 November 2017 / Accepted: 1 December 2017 / Published: 5 December 2017
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The species of the genus Trillium (Melanthiaceae alt. Trilliaceae) include perennial herbs with characteristic rhizomes mainly distributed in Asia and North America. Steroids and saponins are the main classes of phytochemicals present in these plants. This review summarizes and discusses the current knowledge on their chemistry, as well as the in vitro and in vivo studies carried out on the extracts, fractions and isolated pure compounds from the different species belonging to this genus, focusing on core biological properties, i.e., cytotoxic, antifungal and anti-inflammatory activities. View Full-Text
Keywords: bioactive phytochemicals; cytotoxic activity; anti-inflammatory activity; analgesic activity; antifungal activity bioactive phytochemicals; cytotoxic activity; anti-inflammatory activity; analgesic activity; antifungal activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Ur Rahman, S.; Ismail, M.; Khurram, M.; Ullah, I.; Rabbi, F.; Iriti, M. Bioactive Steroids and Saponins of the Genus Trillium. Molecules 2017, 22, 2156.

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