Next Article in Journal
Theoretical Kinetic and Mechanistic Studies on the Reactions of CF3CBrCH2 (2-BTP) with OH and H Radicals
Previous Article in Journal
Bioactive Steroids and Saponins of the Genus Trillium

Support for Natural Small-Molecule Phenols as Anxiolytics

School of Chinese Materia Medica, Beijing University of Chinese Medicine, Liangxiang Town, Fangshan District, Beijing 102488, China
National Institute on Drug Dependence, Peking University, 38#, Xueyuan Road, Haidian District, Beijing 100191, China
Authors to whom correspondence should be addressed.
Molecules 2017, 22(12), 2138;
Received: 29 October 2017 / Revised: 30 November 2017 / Accepted: 30 November 2017 / Published: 6 December 2017
Natural small-molecule phenols (NSMPs) share some bioactivities. The anxiolytic activity of NSMPs is attracting attention in the scientific community. This paper provides data supporting the hypothesis that NSMPs are generally anxiolytic. The anxiolytic activities of seven simple phenols, including phloroglucinol, eugenol, protocatechuic aldehyde, vanillin, thymol, ferulic acid, and caffeic acid, were assayed with the elevated plus maze (EPM) test in mice. The oral doses were 5, 10 and 20 mg/kg, except for phloroglucinol for which the doses were 2.5, 5 and 10 mg/kg. All tested phenols had anxiolytic activity in mice. The phenolic hydroxyl group in 4-hydroxycinnamic acid (4-OH CA) was essential for the anxiolytic activity in the EPM test in mice and rats compared to 4-chlorocinnamic acid (4-Cl CA). The in vivo spike recording of rats’ hippocampal neurons also showed significant differences between 4-OH CA and 4-Cl CA. Behavioral and neuronal spike recording results converged to indicate the hippocampal CA1 region might be a part of the anxiolytic pathways of 4-OH CA. Therefore, our study provides further experimental data supporting NSMPs sharing anxiolytic activity, which may have general implications for phytotherapy because small phenols occur extensively in herbal medicines. View Full-Text
Keywords: anxiety; phenolic hydroxyl group; elevated plus-maze test; phenolic compounds; neuronal spike; hippocampus anxiety; phenolic hydroxyl group; elevated plus-maze test; phenolic compounds; neuronal spike; hippocampus
Show Figures

Figure 1

MDPI and ACS Style

Wang, X.; Chen, Y.; Wang, Q.; Sun, L.; Li, G.; Zhang, C.; Huang, J.; Chen, L.; Zhai, H. Support for Natural Small-Molecule Phenols as Anxiolytics. Molecules 2017, 22, 2138.

AMA Style

Wang X, Chen Y, Wang Q, Sun L, Li G, Zhang C, Huang J, Chen L, Zhai H. Support for Natural Small-Molecule Phenols as Anxiolytics. Molecules. 2017; 22(12):2138.

Chicago/Turabian Style

Wang, Xiaohong, Yahong Chen, Qiang Wang, Lu Sun, Guiyun Li, Chanxi Zhang, Jianmei Huang, Lei Chen, and Haifeng Zhai. 2017. "Support for Natural Small-Molecule Phenols as Anxiolytics" Molecules 22, no. 12: 2138.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop