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Open AccessArticle

Alcohol Interactions with Lipid Bilayers§

1
Department of Physical Chemistry of Drugs, Faculty of Pharmacy, Comenius University in Bratislava, 832 32 Bratislava, Slovakia
2
Frank Laboratory of Neutron Physics, Joint Institute for Nuclear Research, Dubna 141980, Russian
3
Helmholtz-Zentrum Berlin für Materialien und Energie, Macromolecular Crystallography, D-14109 Berlin, Germany
4
Groningen Biomolecular Sciences and Biotechnology Institute and Zernike Institute for Advanced Materials, University of Groningen, 9747 AG Groningen, The Netherlands
*
Author to whom correspondence should be addressed.
§
Dedicated to Daniela Uhríková on the occasion of her birthday anniversary.
Molecules 2017, 22(12), 2078; https://doi.org/10.3390/molecules22122078
Received: 3 November 2017 / Revised: 23 November 2017 / Accepted: 24 November 2017 / Published: 28 November 2017
(This article belongs to the Special Issue Phospholipids: Structure and Function)
We investigate the structural changes to lipid membrane that ensue from the addition of aliphatic alcohols with various alkyl tail lengths. Small angle neutron diffraction from flat lipid bilayers that are hydrated through water vapor has been employed to eliminate possible artefacts of the membrane curvature and the alcohol’s membrane-water partitioning. We have observed clear changes to membrane structure in both transversal and lateral directions. Most importantly, our results suggest the alteration of the membrane-water interface. The water encroachment has shifted in the way that alcohol loaded bilayers absorbed more water molecules when compared to the neat lipid bilayers. The experimental results have been corroborated by molecular dynamics simulations to reveal further details. Namely, the order parameter profiles have been fruitful in correlating the mechanical model of structural changes to the effect of anesthesia. View Full-Text
Keywords: general anesthetics; alcohols; lipid bilayers; small-angle neutron diffraction; molecular dynamics simulations; bilayer thickness; area per lipid; order parameter; lateral pressure general anesthetics; alcohols; lipid bilayers; small-angle neutron diffraction; molecular dynamics simulations; bilayer thickness; area per lipid; order parameter; lateral pressure
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MDPI and ACS Style

Kondela, T.; Gallová, J.; Hauß, T.; Barnoud, J.; Marrink, S.-J.; Kučerka, N. Alcohol Interactions with Lipid Bilayers. Molecules 2017, 22, 2078.

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