Next Article in Journal
A New Series of Pyrrole-Based Chalcones: Synthesis and Evaluation of Antimicrobial Activity, Cytotoxicity, and Genotoxicity
Previous Article in Journal
Recent Advances in Nucleic Acid Targeting Probes and Supramolecular Constructs Based on Pyrene-Modified Oligonucleotides
Open AccessArticle

Antifungal Activity and Action Mode of Cuminic Acid from the Seeds of Cuminum cyminum L. against Fusarium oxysporum f. sp. Niveum (FON) Causing Fusarium Wilt on Watermelon

by Yang Sun 1,†, Yong Wang 1,†, Li Rong Han 1, Xing Zhang 1,2 and Jun Tao Feng 1,2,*
1
Research and Development Center of Biorational Pesticide, Northwest A & F University, Yangling 712100, China
2
Engineering and Research Center of Biological Pesticide of Shaanxi Province, Yangling 712100, China
*
Author to whom correspondence should be addressed.
Joint first authorship.
Molecules 2017, 22(12), 2053; https://doi.org/10.3390/molecules22122053
Received: 31 October 2017 / Revised: 10 November 2017 / Accepted: 21 November 2017 / Published: 30 November 2017
(This article belongs to the Section Natural Products Chemistry)
In order to develop a novel biofungicide, the antifungal activity and action mode of cuminic acid from the seed of Cuminum cyminum L. against Fusarium oxysporum f. sp. niveum (FON) on watermelon was determined systematically. In this study, the median effective concentration (EC50) value for cuminic acid in inhibiting mycelial growth of FON was 22.53 μg/mL. After treatment with cuminic acid, the mycelial morphology was seriously influenced; cell membrane permeability and glycerol content were increased markedly, but pigment and mycotoxin (mainly fusaric acid) were significantly decreased. Synthesis genes of bikaverin (Bike1, Bike2 and Bike3) and fusaric acid (FUB1, FUB2, FUB3 and FUB4) both were downregulated compared with the control, as confirmed by quantitative RT-PCR. In greenhouse experiments, cuminic acid at all concentrations displayed significant bioactivities against FON. Importantly, significant enhancement of activities of SOD, POD, CAT and decrease of MDA content were observed after in vivo cuminic acid treatment on watermelon leaves. These indicated that cuminic acid not only showed high antifungal activity, but also could enhance the self-defense system of the host plant. Above all, cuminic acid showed the potential as a biofungicide to control FON. View Full-Text
Keywords: watermelon fusarium wilt; p-isopropylbenzoic acid; biofungicide; disease management watermelon fusarium wilt; p-isopropylbenzoic acid; biofungicide; disease management
Show Figures

Figure 1

MDPI and ACS Style

Sun, Y.; Wang, Y.; Han, L.R.; Zhang, X.; Feng, J.T. Antifungal Activity and Action Mode of Cuminic Acid from the Seeds of Cuminum cyminum L. against Fusarium oxysporum f. sp. Niveum (FON) Causing Fusarium Wilt on Watermelon. Molecules 2017, 22, 2053.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop