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Molecules 2017, 22(12), 2000;

Design, Synthesis and Bioactivities of Novel Isoxazole-Containing Pyrazole Oxime Derivatives

College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019, China
School of Environmental and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang 212003, China
Analysis and Testing Center, Nantong University, Nantong 226019, China
Authors to whom correspondence should be addressed.
Received: 9 November 2017 / Revised: 24 November 2017 / Accepted: 24 November 2017 / Published: 27 November 2017
(This article belongs to the Section Organic Chemistry)
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In this study, in order to find novel biologically active pyrazole oxime derivatives, twenty-eight new pyrazole oxime compounds containing a substituted isoxazole ring were synthesized and evaluated for their acaricidaland insecticidal activities. Bioassays exhibited that some target compounds indicated good acaricidal and insecticidal activities against Tetranychus cinnabarinus, Aphis medicaginis, Mythimna separata, and Nilaparvata lugens. Especially, compounds 9c, 9h, 9u, and 9v showed 100.00%, 90.56%, 90.78%, and 90.62% insecticidal activities against A. medicaginis at the concentration of 20 μg/mL, respectively, compounds 9k and 9u had 70.86% and 100.00% insecticidal activities against M. separata at 20 μg/mL, respectively. View Full-Text
Keywords: isoxazole; pyrazole oxime; synthesis; bioactivity isoxazole; pyrazole oxime; synthesis; bioactivity

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Dai, H.; Yao, W.; Fang, Y.; Sun, S.; Shi, Y.; Chen, J.; Jiang, G.; Shi, J. Design, Synthesis and Bioactivities of Novel Isoxazole-Containing Pyrazole Oxime Derivatives. Molecules 2017, 22, 2000.

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