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Studies on the Inclusion Complexes of Daidzein with β-Cyclodextrin and Derivatives
Open AccessArticle

Studies on the Anti-Oxidative Function of trans-Cinnamaldehyde-Included β-Cyclodextrin Complex

Department of Food Science and Technology, Chung-ang University, Gyeonggi-do 17546, Korea
Institute of Process Engineering in Life Science, Section I: Food Process Engineering, Karlsruhe Institute of Technology, 76131 Karlsruhe, Germany
Department of Food Science and Biotechnology, Sejong University, 209 Neungdong-ro, Seoul 05006, Korea
Division of Metabolism and Functionality Research, Korea Food Research Institute, 1201-62 Anyangpangyo-ro, Bundang-gu, Seongnam-si, Gyeonggi-do 13539, Korea
Department of Food Science and Biotechnology of Animal Resources, Konkuk University, 120 Neungdong-ro, Seoul 05029, Korea
Authors to whom correspondence should be addressed.
These authors contributed equally to this article.
Molecules 2017, 22(12), 1868;
Received: 31 October 2017 / Revised: 4 December 2017 / Accepted: 16 December 2017 / Published: 19 December 2017
(This article belongs to the Special Issue Extractable and Non-Extractable Antioxidants)
trans-Cinnamaldehyde (tCIN), an active compound found in cinnamon, is well known for its antioxidant, anticancer, and anti-inflammatory activities. The β-cyclodextrin (β-CD) oligomer has been used for a variety of applications in nanotechnology, including pharmaceutical and cosmetic applications. Here, we aimed to evaluate the anti-inflammatory and antioxidant effects of tCIN self-included in β-CD complexes (CIs) in lipopolysaccharide (LPS)-treated murine RAW 264.7 macrophages. RAW 264.7 macrophages were treated with increasing concentrations of β-CD, tCIN, or CIs for different times. β-CD alone did not affect the production of nitric oxide (NO) or reactive oxygen species (ROS). However, both tCIN and CI significantly reduced NO and ROS production. Thus, CIs may have strong anti-inflammatory and antioxidant effects, similar to those of tCIN when used alone. View Full-Text
Keywords: trans-cinnamaldehyde; β-cyclodextrin; self-inclusion; anti-inflammation; antioxidant trans-cinnamaldehyde; β-cyclodextrin; self-inclusion; anti-inflammation; antioxidant
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Davaatseren, M.; Jo, Y.-J.; Hong, G.-P.; Hur, H.J.; Park, S.; Choi, M.-J. Studies on the Anti-Oxidative Function of trans-Cinnamaldehyde-Included β-Cyclodextrin Complex. Molecules 2017, 22, 1868.

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