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Molecules 2017, 22(11), 1859;

New Adducts of Iriflophene and Flavonoids Isolated from Sedum aizoon L. with Potential Antitumor Activity

Department of Medicinal Plants, school of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China
Author to whom correspondence should be addressed.
Received: 15 October 2017 / Revised: 24 October 2017 / Accepted: 24 October 2017 / Published: 2 November 2017
(This article belongs to the Section Natural Products Chemistry)
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Four new special compounds with character of an iriflophene unit and a flavonoid unit connecting via a furan ring were isolated from the roots of Sedum aizoon L. Their corresponding structures were elucidated on the basis of spectroscopic analysis. The in vitro anti-proliferative activities against BXPC-3, A549, and MCF-7 tumor cell lines were evaluated. Compounds 3 and 4 exhibited moderate cytotoxic activities with IC50 ranging from 24.84 to 37.22 μmol L−1, which was capable for further drug exploration. View Full-Text
Keywords: Sedum aizoon L.; iriflophene; flavonoids; antitumor Sedum aizoon L.; iriflophene; flavonoids; antitumor

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Li, M.; Qi, Z.; Hao, Y.; Lv, C.; Jia, L.; Wang, J.; Lu, J. New Adducts of Iriflophene and Flavonoids Isolated from Sedum aizoon L. with Potential Antitumor Activity. Molecules 2017, 22, 1859.

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