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Molecules 2017, 22(11), 1819;

Advances in Fluorescent Single-Chain Nanoparticles

Centro de Física de Materiales (CSIC, UPV/EHU)—MPC, Materials Physics Center, Paseo Manuel de Lardizabal 5, E-20018 San Sebastian, Spain
Departamento de Física de Materiales, Universidad del País Vasco (UPV/EHU), 1072 Apartado, E-20080 San Sebastian, Spain
IKERBASQUE—Basque Foundation for Science, María Díaz de Haro 3, E-48013 Bilbao, Spain
Author to whom correspondence should be addressed.
Received: 29 September 2017 / Revised: 23 October 2017 / Accepted: 25 October 2017 / Published: 26 October 2017
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Fluorophore molecules can be monitored by fluorescence spectroscopy and microscopy, which are highly useful and widely used techniques in cell biology, biochemistry, and medicine (e.g., biomarker analysis, immunoassays, cancer diagnosis). Several fluorescent micro- and nanoparticle systems based on block copolymer micelles and cross-linked polymer networks, quantum dots, π-conjugated polymers, and dendrimers have been evaluated as optical imaging systems. In this review, we highlight recent advances in the construction of fluorescent single-chain nanoparticles (SCNPs), which are valuable artificial soft nano-objects with a small tunable size (as small as 3 nm). In particular, the main methods currently available to endow SCNPs with fluorescent properties are discussed in detail, showing illustrative examples. View Full-Text
Keywords: nanoparticles; fluorescence; optical imaging nanoparticles; fluorescence; optical imaging

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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De-La-Cuesta, J.; González, E.; Pomposo, J.A. Advances in Fluorescent Single-Chain Nanoparticles. Molecules 2017, 22, 1819.

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