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Function Oriented Molecular Design: Dendrimers as Novel Antimicrobials

Organic and Inorganic Chemistry Department, Universidad de Alcalá, Campus Universitario, E-28871 Alcalá de Henares, Spain
Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), 28029 Madrid, Spain
Department of Experimental Medicine, II University of Naples, Via Costantinopoli 16, 80138 Naples, Italy
Interuniversity Research Centre on Bioactive Peptides (CiRPEB), University of Naples “Federico II”, Via Mezzocannone 16, 80134 Naples, Italy
Department of Pharmacy, University of Naples “Federico II”, Via Mezzocannone 16, 80134 Napoli, Italy
John Felice Rome Center, Loyola University Chicago, Via Massimi 114, 00136 Roma, Italy
Authors to whom correspondence should be addressed.
Molecules 2017, 22(10), 1581;
Received: 11 August 2017 / Revised: 8 September 2017 / Accepted: 11 September 2017 / Published: 21 September 2017
(This article belongs to the Special Issue Dendrimers in Medicine)
PDF [1670 KB, uploaded 25 September 2017]


In recent years innovative nanostructures are attracting increasing interest and, among them, dendrimers have shown several fields of application. Dendrimers can be designed and modified in plentiful ways giving rise to hundreds of different molecules with specific characteristics and functionalities. Biomedicine is probably the field where these molecules find extraordinary applicability, and this is probably due to their multi-valency and to the fact that several other chemicals can be coupled to them to obtain desired compounds. In this review we will describe the different production strategies and the tools and technologies for the study of their characteristics. Finally, we provide a panoramic overview of their applications to meet biomedical needs, especially their use as novel antimicrobials. View Full-Text
Keywords: dendrimers; structure; preparation; delivery; antimicrobial; antibacterial; antiviral; antiparasitic dendrimers; structure; preparation; delivery; antimicrobial; antibacterial; antiviral; antiparasitic

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García-Gallego, S.; Franci, G.; Falanga, A.; Gómez, R.; Folliero, V.; Galdiero, S.; De la Mata, F.J.; Galdiero, M. Function Oriented Molecular Design: Dendrimers as Novel Antimicrobials. Molecules 2017, 22, 1581.

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