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Molecules 2017, 22(1), 65;

Assignment of Absolute Configuration of a New Hepatoprotective Schiartane-Type Nortriterpenoid Using X-Ray Diffraction

State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, Medical University of South Carolina, Charleston, SC 29425, USA
Department of Chemistry, Louisiana State University, Baton Rouge, LA 70803, USA
Department of BioMolecular Sciences, Division of Pharmacognosy, and Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, Mississippi 38677-1848, USA
Authors to whom correspondence should be addressed.
Received: 9 December 2016 / Revised: 28 December 2016 / Accepted: 29 December 2016 / Published: 2 January 2017
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A new schiartane-type nortriterpenoid, micrandilactone H was isolated from Kadsura longipedunculata Finet et Gagnep. Its 2D (two dimension) structure was elucidated by NMR spectroscopic analysis, and it is similar to that of Kadnanolactones H and the absolute configuration was established through X-ray diffraction and ECD data analysis. This represents the first complete assignment of the absolute configuration of a schiartane-type nortriterpenoid by X-ray diffraction and the ECD method. Micrandilactone H showed moderate hepatoprotective activity against N-acetyl-p-aminophenol (APAP)-induced toxicity in HepG2 cells with cell survival rates of 56.84% at 10 μM. View Full-Text
Keywords: schiartane-type nortriterpenoid; X-ray; absolute configuration; hepatoprotective schiartane-type nortriterpenoid; X-ray; absolute configuration; hepatoprotective

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Wang, X.; Fronczek, F.R.; Chen, J.; Liu, J.; Ferreira, D.; Li, S.; Hamann, M.T. Assignment of Absolute Configuration of a New Hepatoprotective Schiartane-Type Nortriterpenoid Using X-Ray Diffraction. Molecules 2017, 22, 65.

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