A Selective Cyclic Peptidic Human SIRT5 Inhibitor
AbstractIn the current study, we discovered that a side chain-to-side chain cyclic pentapeptide harboring a central Nε-carboxyethyl-thiocarbamoyl-lysine residue behaved as a strong and selective (versus human SIRT1/2/3/6) inhibitor against human SIRT5-catalyzed deacylation reaction. This compound was also found to be proteolytically much more stable than its linear counterpart. This compound could be a valuable lead for developing stronger, selective, metabolically stable, and cell permeable human SIRT5 inhibitors. View Full-Text
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Liu, J.; Huang, Y.; Zheng, W. A Selective Cyclic Peptidic Human SIRT5 Inhibitor. Molecules 2016, 21, 1217.
Liu J, Huang Y, Zheng W. A Selective Cyclic Peptidic Human SIRT5 Inhibitor. Molecules. 2016; 21(9):1217.Chicago/Turabian Style
Liu, Jiajia; Huang, Yajun; Zheng, Weiping. 2016. "A Selective Cyclic Peptidic Human SIRT5 Inhibitor." Molecules 21, no. 9: 1217.
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