Next Article in Journal
Stability, Antioxidant Capacity and Degradation Kinetics of Pelargonidin-3-glucoside Exposed to Ultrasound Power at Low Temperature
Next Article in Special Issue
Icariin Metabolism by Human Intestinal Microflora
Previous Article in Journal
Ball Milling Assisted Solvent and Catalyst Free Synthesis of Benzimidazoles and Their Derivatives
Previous Article in Special Issue
Beneficial Effects of Trillium govanianum Rhizomes in Pain and Inflammation
Article Menu
Issue 9 (September) cover image

Export Article

Open AccessArticle
Molecules 2016, 21(9), 1110;

In Vivo Metabolite Profiling of a Purified Ellagitannin Isolated from Polygonum capitatum in Rats

State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, China
School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China
Author to whom correspondence should be addressed.
Academic Editor: Marcello Iriti
Received: 24 July 2016 / Revised: 17 August 2016 / Accepted: 19 August 2016 / Published: 24 August 2016
Full-Text   |   PDF [1382 KB, uploaded 24 August 2016]   |  


Ellagitannin is a common compound in food and herbs, but there are few detailed studies on the metabolism of purified ellagitannins. FR429 is a purified ellagitannin with antitumor potential, which is from Polygonum capitatum Buch.-Ham.ex D. Don. The present study was designed to investigate the metabolic profiles of FR429 in rats in vivo. Using liquid chromatography coupled to ion trap time-of-flight mass spectrometry (LC/MSn-IT-TOF), total eight metabolites were found in rat bile and urine after intravenous administration of FR429, but could not be detected in plasma. These metabolites were ellagic acid, mono-methylated FR429, ellagic acid methyl ether glucuronide, ellagic acid methyl ether diglucuronide, ellagic acid dimethyl ether glucuronide, and ellagic acid dimethyl ether diglucuronide. It was concluded that methylation and subsequent glucuronidation were the major metabolic pathways of FR429 in rats in vivo. This is the first report on the in vivo metabolism of the purified ellagitannin in rats. View Full-Text
Keywords: FR429; ellagitannin; metabolite profiling; LC/MSn-IT-TOF FR429; ellagitannin; metabolite profiling; LC/MSn-IT-TOF

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Ma, J.-Y.; Zhou, X.; Fu, J.; He, C.-Y.; Feng, R.; Huang, M.; Shou, J.-W.; Zhao, Z.-X.; Li, X.-Y.; Zhang, L.; Chen, Y.-C.; Wang, Y. In Vivo Metabolite Profiling of a Purified Ellagitannin Isolated from Polygonum capitatum in Rats. Molecules 2016, 21, 1110.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top