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Volume 21
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10.3390/molecules21060815
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Article

Aza-Michael Mono-addition Using Acidic Alumina under Solventless Conditions

by
Giovanna Bosica
* and
Roderick Abdilla
Department of Chemistry, University of Malta, Msida MSD 2080, Malta
*
Author to whom correspondence should be addressed.
Molecules 2016, 21(6), 815; https://doi.org/10.3390/molecules21060815
Submission received: 20 May 2016 / Revised: 10 June 2016 / Accepted: 16 June 2016 / Published: 22 June 2016
(This article belongs to the Special Issue Recent Synthetic Aspects on the Chemistry of Nitro, Nitroso and Amino Compounds)
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Abstract

Aza-Michael reactions between primary aliphatic and aromatic amines and various Michael acceptors have been performed under environmentally-friendly solventless conditions using acidic alumina as a heterogeneous catalyst to selectively obtain the corresponding mono-adducts in high yields. Ethyl acrylate was the main acceptor used, although others such as acrylonitrile, methyl acrylate and acrylamide were also utilized successfully. Bi-functional amines also gave the mono-adducts in good to excellent yields. Such compounds can serve as intermediates for the synthesis of anti-cancer and antibiotic drugs.
Keywords: Aza-Michael reactions; mono-addition; acidic alumina; solvent-free; primary amines Aza-Michael reactions; mono-addition; acidic alumina; solvent-free; primary amines
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MDPI and ACS Style

Bosica, G.; Abdilla, R. Aza-Michael Mono-addition Using Acidic Alumina under Solventless Conditions. Molecules 2016, 21, 815. https://doi.org/10.3390/molecules21060815

AMA Style

Bosica G, Abdilla R. Aza-Michael Mono-addition Using Acidic Alumina under Solventless Conditions. Molecules. 2016; 21(6):815. https://doi.org/10.3390/molecules21060815

Chicago/Turabian Style

Bosica, Giovanna, and Roderick Abdilla. 2016. "Aza-Michael Mono-addition Using Acidic Alumina under Solventless Conditions" Molecules 21, no. 6: 815. https://doi.org/10.3390/molecules21060815

APA Style

Bosica, G., & Abdilla, R. (2016). Aza-Michael Mono-addition Using Acidic Alumina under Solventless Conditions. Molecules, 21(6), 815. https://doi.org/10.3390/molecules21060815

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