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Open AccessArticle

Aza-Michael Mono-addition Using Acidic Alumina under Solventless Conditions

Department of Chemistry, University of Malta, Msida MSD 2080, Malta
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Academic Editor: Alessandro Palmieri
Molecules 2016, 21(6), 815; https://doi.org/10.3390/molecules21060815
Received: 20 May 2016 / Revised: 10 June 2016 / Accepted: 16 June 2016 / Published: 22 June 2016
Aza-Michael reactions between primary aliphatic and aromatic amines and various Michael acceptors have been performed under environmentally-friendly solventless conditions using acidic alumina as a heterogeneous catalyst to selectively obtain the corresponding mono-adducts in high yields. Ethyl acrylate was the main acceptor used, although others such as acrylonitrile, methyl acrylate and acrylamide were also utilized successfully. Bi-functional amines also gave the mono-adducts in good to excellent yields. Such compounds can serve as intermediates for the synthesis of anti-cancer and antibiotic drugs. View Full-Text
Keywords: Aza-Michael reactions; mono-addition; acidic alumina; solvent-free; primary amines Aza-Michael reactions; mono-addition; acidic alumina; solvent-free; primary amines
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MDPI and ACS Style

Bosica, G.; Abdilla, R. Aza-Michael Mono-addition Using Acidic Alumina under Solventless Conditions. Molecules 2016, 21, 815.

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