Quercetin and Its Anti-Allergic Immune Response
Abstract
:1. Introduction
2. Quercetin, Its Structure and Main Sources
3. Antioxidant Activity of Quercetin
4. Polyphenols and Quercetin as Effective Anti-Allergic Secondary Metabolites
4.1. Quercetin and Respiratory Allergic Diseases: In Vitro and Animal Studies
4.2. Quercetin and Respiratory Allergic Diseases—Epidemiological Evidence
4.3. Quercetin and Food Allergies
5. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Effect | Studied Models | Mechanism of Action | References |
---|---|---|---|
Inhibition of mast cell activation | rats | Stabilization of mast cell membrane | Johri et al. [83] |
Inhibition of leucotriens release, prostaglandin D2, Ca2+ influx | Kimata et al. [72] | ||
Human cultured mast cells | Release of IL-6, IL-8, TNF-2, inhibition of tryptase release, activation of NF-κB | Kempuraj
et al. [81], Min et al. [84] | |
Inhibition of histamine release | In vitro malignant cells | Decrease of tryptase, MCP-1, IL-6, histidine decarboxylase (HDC) | Shaik et al. [85] |
Antigen sensitized human mast cells | Normal path of Ca2+ entry to cells, inhibition of leucotrienes, PGD-2 | Fewtrell and Gomperts [86], Kimata et al. [72], Weng et al. [82] | |
Rats mast cells | Release of immunologically induced cells, inhibition of anaphylactic histamine | Haagag
et al. [87] Pearce et al. [88] | |
ovalbumin-challenged mice | release from mucosal cells, inhibited eosinophil peroxidase activity and protein content in bronchoalveolar lavage fluid (BALF) | Kaiser et al. [89] | |
Suppression of eosinophilic inflammation | OVA-induced asthma model rats | Reduction of eosinophil peroxidase activity, level of IL-4, Th2 cytokine production | Park
et al. [90] Chirumbolo [27] Jurikova et al. [8] |
Murine model of asthma | Decrease in eosinophil counts in bronchoalveolar lavage fluid, inhibition of NF-kappa B | Roger
et al. [91] Roger et al. [92] | |
Relaxation of muscles | Male A/J mice | Isoproterenol induced relaxation | Towsend and Emala [93] |
Smoth muscle murine model of asthma | Reduction of production of inflammatory cytokines | Oliveira et al. [94] | |
(OVA)-sensitized conscious guinea pigs | Inhibitory activity of quercetin inhalation on sRaw (specific airway resistance) | Jung
et al. [95] Moon et al. [96] | |
Isolated tracheal tissue | Concentration-dependent inhibition of contractions induced by both carbachol and electrical field stimulation | Capasso et al. [97] | |
Suppression of immunoglobulin E against peanuts proteins | Wister rats | Plasma histamine levels in the quercetin-treated rats were lower significantly, regulate mucosal immunity during hypersensitivity reaction | Shiseboar
et al. [98] Wei et al. [99] |
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Mlcek, J.; Jurikova, T.; Skrovankova, S.; Sochor, J. Quercetin and Its Anti-Allergic Immune Response. Molecules 2016, 21, 623. https://doi.org/10.3390/molecules21050623
Mlcek J, Jurikova T, Skrovankova S, Sochor J. Quercetin and Its Anti-Allergic Immune Response. Molecules. 2016; 21(5):623. https://doi.org/10.3390/molecules21050623
Chicago/Turabian StyleMlcek, Jiri, Tunde Jurikova, Sona Skrovankova, and Jiri Sochor. 2016. "Quercetin and Its Anti-Allergic Immune Response" Molecules 21, no. 5: 623. https://doi.org/10.3390/molecules21050623