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Open AccessArticle

Nanoparticle Effects on Human Platelets in Vitro: A Comparison between PAMAM and Triazine Dendrimers

Department of Chemistry & Biochemistry, Texas Christian University, Fort Worth, TX 76129, USA
Nanotechnology Characterization Lab, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA
Department of Molecular and Medical Genetics & Institute of Cancer Research, University of North Texas Health Science Center, Fort Worth, TX 76109, USA
Authors to whom correspondence should be addressed.
Academic Editor: Ashok Kakkar
Molecules 2016, 21(4), 428;
Received: 3 February 2016 / Revised: 9 March 2016 / Accepted: 21 March 2016 / Published: 29 March 2016
(This article belongs to the Special Issue Functional Dendrimers)
Triazine and PAMAM dendrimers of similar size and number of cationic surface groups were compared for their ability to promote platelet aggregation. Triazine dendrimers (G3, G5 and G7) varied in molecular weight from 8 kDa–130 kDa and in surface groups 16–256. PAMAM dendrimers selected for comparison included G3 (7 kDa, 32 surface groups) and G6 (58 kDa, 256 surface groups). The treatment of human platelet-rich plasma (PRP) with low generation triazine dendrimers (0.01–1 µM) did not show any significant effect in human platelet aggregation in vitro; however, the treatment of PRP with larger generations promotes an effective aggregation. These results are in agreement with studies performed with PAMAM dendrimers, where large generations promote aggregation. Triazine dendrimers promote aggregation less aggressively than PAMAM dendrimers, a factor attributed to differences in cationic charge or the formation of supramolecular assemblies of dendrimers. View Full-Text
Keywords: dendrimer; triazine; PAMAM; platelet; biocompatibility dendrimer; triazine; PAMAM; platelet; biocompatibility
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Enciso, A.E.; Neun, B.; Rodriguez, J.; Ranjan, A.P.; Dobrovolskaia, M.A.; Simanek, E.E. Nanoparticle Effects on Human Platelets in Vitro: A Comparison between PAMAM and Triazine Dendrimers. Molecules 2016, 21, 428.

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