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Molecules 2016, 21(4), 409;

In-Vitro Anticancer Evaluation of Some Novel Thioureido-Benzensulfonamide Derivatives

Department of Pharmacognosy, College of Pharmacy, King Saud University, P. O. Box 2457, Riyadh 11451, Saudi Arabia
Department of Drug Radiation Research, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Nasr City, Cairo 113701, Egypt
Author to whom correspondence should be addressed.
Academic Editors: Jean Jacques Vanden Eynde and Annie Mayence
Received: 29 January 2016 / Revised: 24 February 2016 / Accepted: 26 February 2016 / Published: 25 March 2016
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A novel series of sulfonamide derivatives (14 compounds) bearing thiourea moieties were efficiently synthesized and evaluated for their possible in vitro anticancer activity against four human tumor cell lines. The results indicated that compound 6 was the most potent, showing effectiveness on all the tested cell lines. Compounds 7 and 10 also showed promising results. View Full-Text
Keywords: synthesis; sulfonamides; thioureido; anticancer activity synthesis; sulfonamides; thioureido; anticancer activity

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Ghorab, M.M.; Alsaid, M.S.; Al-Dosari, M.S.; El-Gazzar, M.G.; Arbab, A.H. In-Vitro Anticancer Evaluation of Some Novel Thioureido-Benzensulfonamide Derivatives. Molecules 2016, 21, 409.

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