Next Article in Journal
Isolation of Flavonoids from Deguelia duckeana and Their Effect on Cellular Viability, AMPK, eEF2, eIF2 and eIF4E
Next Article in Special Issue
Preparation and Biological Evaluation of Two Novel Platinum(II) Complexes Based on the Ligands of Dipicolyamine Bisphosphonate Esters
Previous Article in Journal
A Continuous Procedure Based on Column Chromatography to Purify Anthocyanins from Schisandra chinensis by a Macroporous Resin plus Gel Filtration Chromatography
Previous Article in Special Issue
Design of a MCoTI-Based Cyclotide with Angiotensin (1-7)-Like Activity
Open AccessArticle

Synthesis and Anticancer Activities of Glycyrrhetinic Acid Derivatives

Marine College, Shandong University,Weihai 264209, China
Zhong Yuan Academy of Biological Medicine, Liaocheng People’s Hospital/Affiliated Liaocheng Hospital, Taishan Medical University, Liaocheng 252000, China
Authors to whom correspondence should be addressed.
Academic Editors: Jean Jacques Vanden Eynde and Annie Mayence
Molecules 2016, 21(2), 199;
Received: 7 December 2015 / Accepted: 2 February 2016 / Published: 6 February 2016
A total of forty novel glycyrrhetinic acid (GA) derivatives were designed and synthesized. The cytotoxic activity of the novel compounds was tested against two human breast cancer cell lines (MCF-7, MDA-MB-231) in vitro by the MTT method. The evaluation results revealed that, in comparison with GA, compound 42 shows the most promising anticancer activity (IC50 1.88 ± 0.20 and 1.37 ± 0.18 µM for MCF-7 and MDA-MB-231, respectively) and merits further exploration as a new anticancer agent. View Full-Text
Keywords: glycyrrhetinic acid (GA); derivatives; anticancer; MCF-7; MDA-MB-231 glycyrrhetinic acid (GA); derivatives; anticancer; MCF-7; MDA-MB-231
Show Figures

Figure 1

MDPI and ACS Style

Li, Y.; Feng, L.; Song, Z.-F.; Li, H.-B.; Huai, Q.-Y. Synthesis and Anticancer Activities of Glycyrrhetinic Acid Derivatives. Molecules 2016, 21, 199.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop