Nanoparticle-Enabled Transdermal Drug Delivery Systems for Enhanced Dose Control and Tissue Targeting
by
Brian C. Palmer 1 and Lisa A. DeLouise 1,2,3,*
Brian C. Palmer 1 and Lisa A. DeLouise 1,2,3,*
1
Department of Environmental Medicine, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA
2
Department of Biomedical Engineering, School of Engineering and Applied Sciences, University of Rochester, Rochester, NY 14627, USA
3
Department of Dermatology, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Yogeshvar N. Kalia
Molecules 2016, 21(12), 1719; https://doi.org/10.3390/molecules21121719
Received: 24 October 2016 / Revised: 28 November 2016 / Accepted: 9 December 2016 / Published: 15 December 2016
(This article belongs to the Special Issue Transdermal Delivery Systems: Current Landscape and Trends)
Transdermal drug delivery systems have been around for decades, and current technologies (e.g., patches, ointments, and creams) enhance the skin permeation of low molecular weight, lipophilic drugs that are efficacious at low doses. The objective of current transdermal drug delivery research is to discover ways to enhance skin penetration of larger, hydrophilic drugs and macromolecules for disease treatment and vaccination. Nanocarriers made of lipids, metals, or polymers have been successfully used to increase penetration of drugs or vaccines, control drug release, and target drugs to specific areas of skin in vivo. While more research is needed to identify the safety of nanocarriers, this technology has the potential to expand the use of transdermal routes of administration to a wide array of therapeutics. Here, we review the current state of nanoparticle skin delivery systems with special emphasis on targeting skin diseases.
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Keywords:
transdermal; drug; delivery; nanoparticle; nanocarrier; skin; disease
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MDPI and ACS Style
Palmer, B.C.; DeLouise, L.A. Nanoparticle-Enabled Transdermal Drug Delivery Systems for Enhanced Dose Control and Tissue Targeting. Molecules 2016, 21, 1719.
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