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Open AccessArticle

A Novel Synthesis of Fused Uracils: Indenopyrimidopyridazines, Pyrimidopyridazines, and Pyrazolopyrimidines for Antimicrobial and Antitumor Evalution

1
Department of Organic Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Nasr City 11651, Cairo, Egypt
2
Medical Chemistry Department, Faculty of Medicine (Female Section), Jazan University, Jazan 45142, Saudi Arabia
3
Chemistry Department, Faculty of Science (Female Section), Jazan University, Jazan 82621, Saudi Arabia
*
Author to whom correspondence should be addressed.
Academic Editor: Artur Silva
Molecules 2016, 21(12), 1714; https://doi.org/10.3390/molecules21121714
Received: 17 October 2016 / Revised: 6 December 2016 / Accepted: 8 December 2016 / Published: 14 December 2016
A variety of different compounds of fused uracils were prepared simply by the heating of 6-hydrazinyl-1-methyl-, 6-hydrazinyl-1-propyl-, or 6-hydrazinyl-1,3-dipropyluracil under reflux with ninhydrin, isatin, benzylidene malononitrile, benzylylidene ethyl cyanoacetate, benzil, and phenacyl bromide derivatives. The newly synthesized compounds were completely screened for antimicrobial and antitumor activity. View Full-Text
Keywords: 6-chlorouracil; 6-hydrazinyluracils; ninhydrin; isatin indenopyrimidopyridazines; pyrrolopyrimidines; pyrimidopyridazines 6-chlorouracil; 6-hydrazinyluracils; ninhydrin; isatin indenopyrimidopyridazines; pyrrolopyrimidines; pyrimidopyridazines
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MDPI and ACS Style

El-Kalyoubi, S.; Agili, F. A Novel Synthesis of Fused Uracils: Indenopyrimidopyridazines, Pyrimidopyridazines, and Pyrazolopyrimidines for Antimicrobial and Antitumor Evalution. Molecules 2016, 21, 1714. https://doi.org/10.3390/molecules21121714

AMA Style

El-Kalyoubi S, Agili F. A Novel Synthesis of Fused Uracils: Indenopyrimidopyridazines, Pyrimidopyridazines, and Pyrazolopyrimidines for Antimicrobial and Antitumor Evalution. Molecules. 2016; 21(12):1714. https://doi.org/10.3390/molecules21121714

Chicago/Turabian Style

El-Kalyoubi, Samar; Agili, Fatimah. 2016. "A Novel Synthesis of Fused Uracils: Indenopyrimidopyridazines, Pyrimidopyridazines, and Pyrazolopyrimidines for Antimicrobial and Antitumor Evalution" Molecules 21, no. 12: 1714. https://doi.org/10.3390/molecules21121714

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