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Open AccessArticle

Identification of Novel Human Breast Carcinoma (MDA-MB-231) Cell Growth Modulators from a Carbohydrate-Based Diversity Oriented Synthesis Library

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Department of Chemistry “Ugo Schiff”, University of Florence, Via della Lastruccia 13, 50019 Sesto Fiorentino, Florence, Italy
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Department of Clinical and Experimental Biomedical Science “Mario Serio”, University of Florence, Viale Morgagni 50, 50134 Florence, Italy
*
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Molecules 2016, 21(10), 1405; https://doi.org/10.3390/molecules21101405
Received: 18 August 2016 / Revised: 12 October 2016 / Accepted: 15 October 2016 / Published: 20 October 2016
(This article belongs to the Special Issue Diversity Oriented Synthesis 2016)
The application of a cell-based growth inhibition on a library of skeletally different glycomimetics allowed for the selection of a hexahydro-2H-furo[3,2-b][1,4]oxazine compound as candidate inhibitors of MDA-MB-231 cell growth. Subsequent synthesis of analogue compounds and preliminary biological studies validated the selection of a valuable hit compound with a novel polyhydroxylated structure for the modulation of the breast carcinoma cell cycle mechanism. View Full-Text
Keywords: heterocycles; sugars; chemical diversity; cancer heterocycles; sugars; chemical diversity; cancer
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Lenci, E.; Innocenti, R.; Biagioni, A.; Menchi, G.; Bianchini, F.; Trabocchi, A. Identification of Novel Human Breast Carcinoma (MDA-MB-231) Cell Growth Modulators from a Carbohydrate-Based Diversity Oriented Synthesis Library. Molecules 2016, 21, 1405.

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