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Relationship between the Ingestion of a Polyphenol-Rich Drink, Hepcidin Hormone, and Long-Term Training

Department of Food Science and Technology, CEBAS-CSIC, Campus de Espinardo 25, Espinardo, Murcia 30100, Spain
Faculty of Education, University of Alicante, Campus de Sant Vicent del Raspeig, Alicante 03690, Spain
Authors to whom correspondence should be addressed.
These authors contribute equally to this work.
Academic Editors: Derek J. McPhee and Pedro Mena
Molecules 2016, 21(10), 1333;
Received: 29 June 2016 / Revised: 28 September 2016 / Accepted: 1 October 2016 / Published: 8 October 2016
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The effects of polyphenol-rich foods on the iron status of athletes, as well as the effect of physical training on the hormone hepcidin, implicated in iron metabolism, are not clear. We investigated the influence on iron metabolism of a long-term training intervention of 120 days, measuring the hepcidin concentration in the plasma of 16 elite triathletes, and the effect of the ingestion of 200 mL of either aronia-citrus juice or a placebo drink for 45 days, in a crossover design. The highest plasma hepcidin concentrations were observed at the beginning of the study (116 ± 63 nM) and levels steadily decreased until the end of the intervention (final value 10 ± 7.5 nM). Long-term training might reduce inflammation and, hence, could be responsible for the decrease in hepcidin in triathletes. Polyphenols from aronia-citrus juice did not interfere in iron absorption, as we did not observe significant differences between the intake of the placebo drink or juice with regard to hepcidin levels. Further studies are required to ascertain the time and conditions necessary to restore hepcidin levels, which reflect the iron status of triathletes. View Full-Text
Keywords: polyphenols; hepcidin; iron; exercise; juice polyphenols; hepcidin; iron; exercise; juice

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Villaño, D.; Vilaplana, C.; Medina, S.; Algaba-Chueca, F.; Cejuela-Anta, R.; Martínez-Sanz, J.M.; Ferreres, F.; Gil-Izquierdo, A. Relationship between the Ingestion of a Polyphenol-Rich Drink, Hepcidin Hormone, and Long-Term Training. Molecules 2016, 21, 1333.

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