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Molecules 2016, 21(1), 57;

Evaluation of the Nano-TiO2 as a Novel Deswelling Material

Department of Immunology, School of Basic Medical Sciences, Peking University, Beijing 100191, China
Key Laboratory of Medical Immunology, Ministry of Health, Beijing 100191, China
Pharmacy Department, Liao Ning University of Traditional Chinese Medicine, Shenyang 116600, Liao Ning, China
Authors to whom correspondence should be addressed.
Academic Editor: Didier Astruc
Received: 26 September 2015 / Revised: 18 December 2015 / Accepted: 28 December 2015 / Published: 4 January 2016
(This article belongs to the Collection Nanomedicine)
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Nano-TiO2 is widely applied in the automobile exhaust hose reels as a catalyst to reduce oxynitride emissions, including nitric oxide (NO). In the biomedicine field, NO plays an important role in vasodilation and edema formation in human bodies. However, the deswelling activity of nano-TiO2 has not been reported. Here, we demonstrated that nano-TiO2 can significantly degrade the production of NO in LPS-induced RAW264.7 mouse macrophages. Further study indicated that nano-TiO2 exhibited an effect on vascular permeability inhibition, and prevented carrageenan-induced footpad edema. Therefore, we prepared a nano-TiO2 ointment and observed similar deswelling effects. In conclusion, nano-TiO2 might act as a novel deswelling agent related with its degradation of NO, which will aid in our ability to design effective interventions for edema involved diseases. View Full-Text
Keywords: nano-TiO2; nitric oxide; deswelling activity; vascular permeability; nano-TiO2 ointment nano-TiO2; nitric oxide; deswelling activity; vascular permeability; nano-TiO2 ointment

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Chu, M.; Hou, Y.-L.; Xu, L.; Chu, Z.-Y.; Zhang, M.-B.; Wang, Y.-D. Evaluation of the Nano-TiO2 as a Novel Deswelling Material. Molecules 2016, 21, 57.

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