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Anti-Inflammatory Activities of Licorice Extract and Its Active Compounds, Glycyrrhizic Acid, Liquiritin and Liquiritigenin, in BV2 Cells and Mice Liver

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Department of Molecular Medicine and Tissue Injury Defense Research Center, School of Medicine, Ewha Womans University, Yangchon-ku, Seoul 158-710, Korea
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Life Science Research Institute, Novarex Co., Ltd, Ochang, Cheongwon, Chungbuk 363-885, Korea
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College of Pharmacy, Pusan National University, Pusan 609-735, Korea
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Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Molecules 2015, 20(7), 13041-13054; https://doi.org/10.3390/molecules200713041
Received: 14 May 2015 / Revised: 8 July 2015 / Accepted: 10 July 2015 / Published: 20 July 2015
(This article belongs to the Section Metabolites)
This study provides the scientific basis for the anti-inflammatory effects of licorice extract in a t-BHP (tert-butyl hydrogen peroxide)-induced liver damage model and the effects of its ingredients, glycyrrhizic acid (GA), liquiritin (LQ) and liquiritigenin (LG), in a lipopolysaccharide (LPS)-stimulated microglial cell model. The GA, LQ and LG inhibited the LPS-stimulated elevation of pro-inflammatory mediators, such as inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and interleukin (IL)-6 in BV2 (mouse brain microglia) cells. Furthermore, licorice extract inhibited the expression levels of pro-inflammatory cytokines (TNF-α, IL-1β and IL-6) in the livers of t-BHP-treated mice models. This result suggested that mechanistic-based evidence substantiating the traditional claims of licorice extract and its three bioactive components can be applied for the treatment of inflammation-related disorders, such as oxidative liver damage and inflammation diseases. View Full-Text
Keywords: licorice extract; oxidative liver damage; anti-inflammation; glycyrrhizic acid; liquiritin; hepatoprotective effect licorice extract; oxidative liver damage; anti-inflammation; glycyrrhizic acid; liquiritin; hepatoprotective effect
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Yu, J.-Y.; Ha, J.Y.; Kim, K.-M.; Jung, Y.-S.; Jung, J.-C.; Oh, S. Anti-Inflammatory Activities of Licorice Extract and Its Active Compounds, Glycyrrhizic Acid, Liquiritin and Liquiritigenin, in BV2 Cells and Mice Liver. Molecules 2015, 20, 13041-13054.

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