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68Ga-Based Radiopharmaceuticals: Production and Application Relationship

Section of Nuclear Medicine and PET, Department of Surgical Sciences, Uppsala University, Uppsala SE-751 85, Sweden
PET Center, Center for Medical Imaging, Uppsala University Hospital, Uppsala SE-751 85, Sweden 
Academic Editor: Svend Borup Jensen
Molecules 2015, 20(7), 12913-12943;
Received: 7 June 2015 / Revised: 25 June 2015 / Accepted: 6 July 2015 / Published: 16 July 2015
(This article belongs to the Special Issue Preparation of Radiopharmaceuticals and Their Use in Drug Development)
PDF [5371 KB, uploaded 16 July 2015]


The contribution of 68Ga to the promotion and expansion of clinical research and routine positron emission tomography (PET) for earlier better diagnostics and individualized medicine is considerable. The potential applications of 68Ga-comprising imaging agents include targeted, pre-targeted and non-targeted imaging. This review discusses the key aspects of the production of 68Ga and 68Ga-based radiopharmaceuticals in the light of the impact of regulatory requirements and endpoint pre-clinical and clinical applications. View Full-Text
Keywords: positron emission tomography; 68Ga; chemistry; receptor targeting; peptide; GMP; dosimetry positron emission tomography; 68Ga; chemistry; receptor targeting; peptide; GMP; dosimetry

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Velikyan, I. 68Ga-Based Radiopharmaceuticals: Production and Application Relationship. Molecules 2015, 20, 12913-12943.

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