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Curcumin, Inflammation, and Chronic Diseases: How Are They Linked?

by Yan He 1,†, Yuan Yue 1,†, Xi Zheng 1,2, Kun Zhang 1, Shaohua Chen 3 and Zhiyun Du 1,*
Institute of Natural Medicine & Green Chemistry, School of Chemical Engineering and Light Industry, Guandong University of Technology, 232 Wai Huan West Road, Guangzhou Higher Education Mega Center, Guangzhou 510006, China
Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
Department of Otorhinolaryngology, Guangdong General Hospital & Guangdong Academy of Medical Sciences, Guangzhou 510030, China
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Bharat B. Aggarwal and Sahdeo Prasad
Molecules 2015, 20(5), 9183-9213;
Received: 25 January 2015 / Revised: 11 May 2015 / Accepted: 14 May 2015 / Published: 20 May 2015
(This article belongs to the Special Issue Curcumin, Inflammation, and Chronic Diseases: How are They Linked?)
It is extensively verified that continued oxidative stress and oxidative damage may lead to chronic inflammation, which in turn can mediate most chronic diseases including cancer, diabetes, cardiovascular, neurological, inflammatory bowel disease and pulmonary diseases. Curcumin, a yellow coloring agent extracted from turmeric, shows strong anti-oxidative and anti-inflammatory activities when used as a remedy for the prevention and treatment of chronic diseases. How oxidative stress activates inflammatory pathways leading to the progression of chronic diseases is the focus of this review. Thus, research to date suggests that chronic inflammation, oxidative stress, and most chronic diseases are closely linked, and the antioxidant properties of curcumin can play a key role in the prevention and treatment of chronic inflammation diseases. View Full-Text
Keywords: curcumin; antioxidant; inflammation; chronic diseases curcumin; antioxidant; inflammation; chronic diseases
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MDPI and ACS Style

He, Y.; Yue, Y.; Zheng, X.; Zhang, K.; Chen, S.; Du, Z. Curcumin, Inflammation, and Chronic Diseases: How Are They Linked? Molecules 2015, 20, 9183-9213.

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