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Article

Cytotoxic Lignan from the Non-Transformed Root Culture of Phyllanthus amarus

1
Department of Pharmacognosy with Medicinal Plants Garden, Medical University of Gdańsk, Gdańsk 80-210, Poland
2
Department of Biotechnology, Intercollegiate Faculty of Biotechnology, University of Gdańsk and Medical University of Gdańsk, Gdańsk 80-822, Poland
3
NMR Laboratory, Faculty of Chemistry, Technical University of Gdańsk, Gdańsk 80-233, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Molecules 2015, 20(5), 7915-7924; https://doi.org/10.3390/molecules20057915
Received: 20 February 2015 / Revised: 17 April 2015 / Accepted: 22 April 2015 / Published: 30 April 2015
(This article belongs to the Section Natural Products Chemistry)
A new lignan from the non-transformed root in vitro cultures of Phyllanthus amarus was isolated. The structure of the compound was established on the basis of one- and two-dimensional NMR, as well as mass spectrometry data, as 7'-oxocubebin dimethylether (1,4-bis(benzo[d][1,3]dioxol-5-yl)-2,3-bis(methoxymethyl)butan-1-on). The non-transformed root cultures of P. amarus showed to be a selective source of this compound. The lignan revealed strong cytotoxic activity against HeLa cell line with an IC50 value of 3.8 µg/mL. View Full-Text
Keywords: Phyllanthus amarus; 7'-oxocubebin dimethylether; cytotoxic activity; in vitro culture Phyllanthus amarus; 7'-oxocubebin dimethylether; cytotoxic activity; in vitro culture
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MDPI and ACS Style

Sparzak, B.; Krauze-Baranowska, M.; Kawiak, A.; Sowiński, P. Cytotoxic Lignan from the Non-Transformed Root Culture of Phyllanthus amarus. Molecules 2015, 20, 7915-7924. https://doi.org/10.3390/molecules20057915

AMA Style

Sparzak B, Krauze-Baranowska M, Kawiak A, Sowiński P. Cytotoxic Lignan from the Non-Transformed Root Culture of Phyllanthus amarus. Molecules. 2015; 20(5):7915-7924. https://doi.org/10.3390/molecules20057915

Chicago/Turabian Style

Sparzak, Barbara; Krauze-Baranowska, Mirosława; Kawiak, Anna; Sowiński, Paweł. 2015. "Cytotoxic Lignan from the Non-Transformed Root Culture of Phyllanthus amarus" Molecules 20, no. 5: 7915-7924. https://doi.org/10.3390/molecules20057915

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