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Open AccessArticle

Synthesis of Novel Dihydropyridothienopyrimidin-4,9-dione Derivatives

Center for Neuro-Medicine, Korea Institute of Science and Technology, Seongbuk-gu, Seoul 136-791, Korea
Department of Chemistry, Yonsei University, Seodaemun-gu, Seoul 120-749, Korea
Department of Chemistry, College of Natural Sciences, Sangmyung University, Seoul 110-743, Korea
Department of Biological Chemistry, University of Science and Technology, Youseong-gu, Daejeon 305-350, Korea
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Molecules 2015, 20(3), 5074-5084;
Received: 27 January 2015 / Revised: 12 March 2015 / Accepted: 13 March 2015 / Published: 19 March 2015
(This article belongs to the Section Organic Chemistry)
A novel molecular scaffold, dihydropyridothienopyrimidin-4,9-dione, was synthesized from benzylamine or p-methoxybenzylamine in six steps involving successive ring closure to form a fused ring system composed of dihydropyridone, thiophene and pyrimidone. The pharmacological versatility of the dihydropyridothenopyrimidin-4,9-dione scaffold was demonstrated by inhibitory activity against metabotropic glutamate receptor subtype 1 (mGluR1), which shows that the title compounds can serve as an interesting scaffold for the discovery of potential bioactive molecules for the treatment of human diseases. View Full-Text
Keywords: dihydropyridothienopyrimidin-4,9-dione; pyridothienopyrimidine; successive ring formation dihydropyridothienopyrimidin-4,9-dione; pyridothienopyrimidine; successive ring formation
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Kim, Y.; Kim, M.; Park, M.; Tae, J.; Baek, D.-J.; Park, K.D.; Choo, H. Synthesis of Novel Dihydropyridothienopyrimidin-4,9-dione Derivatives. Molecules 2015, 20, 5074-5084.

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