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Keywords = dihydropyridothienopyrimidin-4,9-dione

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11 pages, 707 KiB  
Article
Synthesis of Novel Dihydropyridothienopyrimidin-4,9-dione Derivatives
by Youngjae Kim, Minjoo Kim, Mooseong Park, Jinsung Tae, Du-Jong Baek, Ki Duk Park and Hyunah Choo
Molecules 2015, 20(3), 5074-5084; https://doi.org/10.3390/molecules20035074 - 19 Mar 2015
Cited by 8 | Viewed by 6216
Abstract
A novel molecular scaffold, dihydropyridothienopyrimidin-4,9-dione, was synthesized from benzylamine or p-methoxybenzylamine in six steps involving successive ring closure to form a fused ring system composed of dihydropyridone, thiophene and pyrimidone. The pharmacological versatility of the dihydropyridothenopyrimidin-4,9-dione scaffold was demonstrated by inhibitory activity [...] Read more.
A novel molecular scaffold, dihydropyridothienopyrimidin-4,9-dione, was synthesized from benzylamine or p-methoxybenzylamine in six steps involving successive ring closure to form a fused ring system composed of dihydropyridone, thiophene and pyrimidone. The pharmacological versatility of the dihydropyridothenopyrimidin-4,9-dione scaffold was demonstrated by inhibitory activity against metabotropic glutamate receptor subtype 1 (mGluR1), which shows that the title compounds can serve as an interesting scaffold for the discovery of potential bioactive molecules for the treatment of human diseases. Full article
(This article belongs to the Section Organic Chemistry)
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