Next Article in Journal
Synthesis of Peptide Nucleic Acids Containing a Crosslinking Agent and Evaluation of Their Reactivities
Next Article in Special Issue
Understanding the Physicochemical Properties of Mitragynine, a Principal Alkaloid of Mitragyna speciosa, for Preclinical Evaluation
Previous Article in Journal
Simultaneous Determination of Ferulic Acid and Phthalides of Angelica Sinensis Based on UPLC-Q-TOF/MS
Previous Article in Special Issue
Indole Alkaloids from Catharanthus roseus: Bioproduction and Their Effect on Human Health
Article Menu

Export Article

Open AccessReview
Molecules 2015, 20(3), 4695-4707;

Anti-Allergic Properties of Curine, a Bisbenzylisoquinoline Alkaloid

Laboratório de Imunofarmacologia, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, RJ 21040-360, Brazil
Laboratório de Imunofarmacologia, Departamento de Fisiologia e Patologia, UFPB, João Pessoa, Pb 58051-900, Brazil
Author to whom correspondence should be addressed.
Academic Editor: Patricia Valentao
Received: 31 October 2014 / Revised: 13 February 2015 / Accepted: 16 February 2015 / Published: 13 March 2015
(This article belongs to the Special Issue Alkaloids: Novel Therapeutic Perspectives)
Full-Text   |   PDF [1123 KB, uploaded 13 March 2015]   |  


Curine is a bisbenzylisoquinoline alkaloid isolated from Chondrodendron platyphyllum (Menispermaceae). Recent findings have shed light on the actions of curine in different models of allergy and inflammation. Here we review the properties and mechanisms of action of curine focusing on its anti-allergic effects. Curine pre-treatment significantly inhibited the scratching behavior, paw edema and systemic anaphylaxis induced by either ovalbumin (OVA) in sensitized animals or compound 48/80, through mechanisms of mast cell stabilization and inhibition of mast cell activation to generate lipid mediators. In addition, oral administration of curine significantly inhibited eosinophil recruitment and activation, as well as, OVA-induced airway hyper-responsiveness in a mouse model of asthma, through inhibition of the production of IL-13 and eotaxin, and of Ca2+ influx. In conclusion, curine exhibit anti-allergic effects in models of lung, skin and systemic allergy in the absence of significant toxicity, and as such has the potential for anti-allergic drug development. View Full-Text
Keywords: curine; anti-allergic; asthma; calcium; mast cells; eosinophils curine; anti-allergic; asthma; calcium; mast cells; eosinophils

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Ribeiro-Filho, J.; Piuvezam, M.R.; Bozza, P.T. Anti-Allergic Properties of Curine, a Bisbenzylisoquinoline Alkaloid. Molecules 2015, 20, 4695-4707.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top