Next Article in Journal
Assessing Chemical Constituents of Mimosa caesalpiniifolia Stem Bark: Possible Bioactive Components Accountable for the Cytotoxic Effect of M. caesalpiniifolia on Human Tumour Cell Lines
Next Article in Special Issue
Antileishmanial and Cytotoxic Compounds from Valeriana wallichii and Identification of a Novel Nepetolactone Derivative
Previous Article in Journal
Chemical Constituents and Structural Characterization of Polysaccharides from Four Typical Bamboo Species Leaves
Previous Article in Special Issue
The Role of Phosphoglycans in the Susceptibility of Leishmania mexicana to the Temporin Family of Anti-Microbial Peptides

Natural Products for the Treatment of Trachoma and Chlamydia trachomatis

by 1,2 and 1,2,*
School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore
Centre for Biomimetic Sensor Science, 50 Nanyang Drive, Singapore 637553, Singapore
Author to whom correspondence should be addressed.
Academic Editor: Thomas J. Schmidt
Molecules 2015, 20(3), 4180-4203;
Received: 15 December 2014 / Revised: 11 February 2015 / Accepted: 24 February 2015 / Published: 5 March 2015
The neglected tropical disease (NTD) trachoma is currently the leading cause of eye disease in the world, and the pathogenic bacteria causing this condition, Chlamydia trachomatis, is also the most common sexually transmitted pathogenic bacterium. Although the serovars of this bacterial species typically vary between ocular and genital infections there is a clear connection between genital C. trachomatis infections and the development of trachoma in infants, such that the solutions to these infections are closely related. It is the unique life cycle of the C. trachomatis bacteria which primarily leads to chronic infections and challenges in treatment using conventional antibiotics. This life cycle involves stages of infective elementary bodies (EBs) and reproductive reticulate bodies (RBs). Most antibiotics only target the reproductive RBs and this often leads to the need for prolonged therapy which facilitates the development of drug resistant pathogens. It is through combining several compounds to obtain multiple antimicrobial mechanisms that we are most likely to develop a reliable means to address all these issues. Traditional and ethnobotanical medicine provides valuable resources for the development of novel formulations and treatment regimes based on synergistic and multi-compound therapy. In this review we intend to summarize the existing literature on the application of natural compounds for controlling trachoma and inhibiting chlamydial bacteria and explore the potential for the development of new treatment modalities. View Full-Text
Keywords: trachoma; Chlamydia trachomatis; natural products; antibacterial trachoma; Chlamydia trachomatis; natural products; antibacterial
Show Figures

Figure 1

MDPI and ACS Style

Potroz, M.G.; Cho, N.-J. Natural Products for the Treatment of Trachoma and Chlamydia trachomatis. Molecules 2015, 20, 4180-4203.

AMA Style

Potroz MG, Cho N-J. Natural Products for the Treatment of Trachoma and Chlamydia trachomatis. Molecules. 2015; 20(3):4180-4203.

Chicago/Turabian Style

Potroz, Michael G., and Nam-Joon Cho. 2015. "Natural Products for the Treatment of Trachoma and Chlamydia trachomatis" Molecules 20, no. 3: 4180-4203.

Find Other Styles

Article Access Map by Country/Region

Only visits after 24 November 2015 are recorded.
Back to TopTop