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Comment published on 14 January 2016, see Molecules 2016, 21(1), 93.

Open AccessArticle

Divinyl Sulfone Cross-Linked Cyclodextrin-Based Polymeric Materials: Synthesis and Applications as Sorbents and Encapsulating Agents

Departamento de Química Orgánica, Facultad de Ciencias, Instituto de Biotecnología, Universidad de Granada, E1871 Granada, Spain
Department of Chemistry, Faculty of Science, Sohag University, Sohag 82524, Egypt
Authors to whom correspondence should be addressed.
Academic Editor: Eduardo Sobarzo-Sánchez
Molecules 2015, 20(3), 3565-3581;
Received: 18 November 2014 / Accepted: 13 February 2015 / Published: 19 February 2015
PDF [3192 KB, uploaded 20 February 2015]


The aim of this study was to evaluate the crosslinking abilities of divinyl sulfone (DVS) for the preparation of novel water-insoluble cyclodextrin-based polymers (CDPs) capable of forming inclusion complexes with different guest molecules. Reaction of DVS with native α-cyclodextrin (α-CD), β-cyclodextrin (β-CD) and/or starch generates a variety of homo- and hetero-CDPs with different degrees of crosslinking as a function of the reactants’ stoichiometric ratio. The novel materials were characterized by powder X-ray diffraction, electron microscopy and for their sorption of phenol and 4-nitrophenol. They were further evaluated as sorbents with phenolic pollutants (bisphenol A and β-naphthol) and bioactive compounds (the hormone progesterone and curcumin). Data obtained from the inclusion experiments show that the degree of cross-linking has a minor influence on the yield of inclusion complex formation and highlight the important role of the CDs, supporting a sorption process based on the formation of inclusion complexes. In general, the inclusion processes are better described by a Freundlich isotherm although an important number of them can also be fitted to the Langmuir isotherm with R2 ≥ 0.9, suggesting a sorption onto a monolayer of homogeneous sites. View Full-Text
Keywords: cyclodextrins; divinyl sulfone; sorbents, encapsulating agents; phenols; curcumin cyclodextrins; divinyl sulfone; sorbents, encapsulating agents; phenols; curcumin

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Morales-Sanfrutos, J.; Lopez-Jaramillo, F.J.; Elremaily, M.A.A.; Hernández-Mateo, F.; Santoyo-Gonzalez, F. Divinyl Sulfone Cross-Linked Cyclodextrin-Based Polymeric Materials: Synthesis and Applications as Sorbents and Encapsulating Agents. Molecules 2015, 20, 3565-3581.

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