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Molecules 2015, 20(11), 19775-19788;

The Phe-Phe Motif for Peptide Self-Assembly in Nanomedicine

Chemical and Pharmaceutical Sciences Department, University of Trieste, Via L. Giorgieri 1, Trieste 34127, Italy
Department of Physics, University of Cagliari, Cittadella Universitaria S.P. Monserrato-Sestu Km. 0.700, Monserrato 09042, Italy
CSIRO Manufacturing, Bayview Ave Clayton, VIC 3168, Australia
Author to whom correspondence should be addressed.
Academic Editor: Didier Astruc
Received: 30 September 2015 / Revised: 25 October 2015 / Accepted: 27 October 2015 / Published: 3 November 2015
(This article belongs to the Collection Nanomedicine)
Full-Text   |   PDF [2664 KB, uploaded 3 November 2015]   |  


Since its discovery, the Phe-Phe motif has gained in popularity as a minimalist building block to drive the self-assembly of short peptides and their analogues into nanostructures and hydrogels. Molecules based on the Phe-Phe motif have found a range of applications in nanomedicine, from drug delivery and biomaterials to new therapeutic paradigms. Here we discuss the various production methods for this class of compounds, and the characterization, nanomorphologies, and application of their self-assembled nanostructures. We include the most recent findings on their remarkable properties, which hold substantial promise for the creation of the next generation nanomedicines. View Full-Text
Keywords: diphenylalanine; self-assembly; hydrogels; peptides; nanostructures diphenylalanine; self-assembly; hydrogels; peptides; nanostructures

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Marchesan, S.; Vargiu, A.V.; Styan, K.E. The Phe-Phe Motif for Peptide Self-Assembly in Nanomedicine. Molecules 2015, 20, 19775-19788.

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