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Quaternary Alkylammonium Conjugates of Steroids: Synthesis, Molecular Structure, and Biological Studies

Laboratory of Microbiocides Chemistry, Faculty of Chemistry, Adam Mickiewicz University, Umultowska 89b, 61-614 Poznań, Poland
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Academic Editor: Roman Dembinski
Molecules 2015, 20(11), 20887-20900; https://doi.org/10.3390/molecules201119735
Received: 23 October 2015 / Revised: 15 November 2015 / Accepted: 17 November 2015 / Published: 23 November 2015
(This article belongs to the Section Organic Chemistry)
The methods of synthesis as well as physical, spectroscopic (1H-NMR, 13C-NMR, and FT-IR, ESI-MS), and biological properties of quaternary and dimeric quaternary alkylammonium conjugates of steroids are presented. The results were contrasted with theoretical calculations (PM5 methods) and potential pharmacological properties (PASS). Alkylammonium sterols exhibit a broad spectrum of antimicrobial activity comparable to squalamine. View Full-Text
Keywords: squalamine; bile acids; sterols; quaternary alkylammonium salt; conjugates; prediction of activity spectra for substances (PASS); PM5 calculations squalamine; bile acids; sterols; quaternary alkylammonium salt; conjugates; prediction of activity spectra for substances (PASS); PM5 calculations
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Brycki, B.; Koenig, H.; Pospieszny, T. Quaternary Alkylammonium Conjugates of Steroids: Synthesis, Molecular Structure, and Biological Studies. Molecules 2015, 20, 20887-20900.

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