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Molecules 2015, 20(10), 19433-19448;

The Multiple Roles of Microrna-223 in Regulating Bone Metabolism

2,* and 1,*
Department of Orthopedics, General Hospital of Chinese PLA, Beijing 100853, China
National Key Laboratory of Medical Molecular Biology, Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing 100005, China
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 14 September 2015 / Revised: 13 October 2015 / Accepted: 20 October 2015 / Published: 23 October 2015
(This article belongs to the Section Molecular Diversity)
Full-Text   |   PDF [759 KB, uploaded 23 October 2015]   |  


Bone metabolism is a lifelong process for maintaining skeletal system homeostasis, which is regulated by bone-resorbing osteoclasts and bone-forming osteoblasts. Aberrant differentiation of osteoclasts and osteoblasts leads to imbalanced bone metabolism, resulting in ossification and osteolysis diseases. MicroRNAs (miRNAs) are pivotal factors in regulating bone metabolism via post-transcriptional inhibition of target genes. Recent studies have revealed that miR-223 exerts multiple effects on bone metabolism, especially in the processes of osteoclast and osteoblasts differentiation. In this review, we highlight the roles of miR-223 during the processes of osteoclast and osteoblast differentiation, as well as the potential clinical applications of miR-223 in bone metabolism disorders. View Full-Text
Keywords: miR-223; osteoclast; osteoblast; bone metabolism miR-223; osteoclast; osteoblast; bone metabolism

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Xie, Y.; Zhang, L.; Gao, Y.; Ge, W.; Tang, P. The Multiple Roles of Microrna-223 in Regulating Bone Metabolism. Molecules 2015, 20, 19433-19448.

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