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Molecules 2015, 20(10), 18001-18015;

Cucurbitacins from the Leaves of Citrullus colocynthis (L.) Schrad

Université de Toulouse, UPS, Pharma-DEV, UMR 152, Université Toulouse 3, Faculté des Sciences Pharmaceutiques, F-31062 Toulouse cedex 09, France
Institut de Recherche pour le Développement (IRD), UMR 152 Pharma-DEV, F-31062 Toulouse cedex 09, France
Laboratoire de Chimie des Substances Naturelles, Faculté des Sciences de Sfax, Université de Sfax Route de l'aéroport, BP 1171, 3000 Sfax, Tunisie
INSERM U1043, CNRS U5282, Université de Toulouse, UPS, Centre de Physiopathologie de Toulouse Purpan, F-31300 Toulouse, France
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 8 July 2015 / Revised: 14 September 2015 / Accepted: 23 September 2015 / Published: 30 September 2015
(This article belongs to the Section Natural Products Chemistry)
Full-Text   |   PDF [885 KB, uploaded 30 September 2015]   |  


Two new tetracyclic cucurbitane-type triterpene glycosides were isolated from an ethyl acetate extract of Citrullus colocynthis leaves together with four known cucurbitacins. Their structures were established on the basis of their spectroscopic data (mainly NMR and mass spectrometry). Evaluation of the in vitro cytotoxic activity of the isolated compounds against two human colon cancer cell lines (HT29 and Caco-2) and one normal rat intestine epithelial cell line (IEC6), revealed that one of the isolated compounds presented interesting specific cytotoxic activity towards colorectal cell lines. View Full-Text
Keywords: Citrullus colocynthis; cucurbitacins; cytotoxicity Citrullus colocynthis; cucurbitacins; cytotoxicity

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Chawech, R.; Jarraya, R.; Girardi, C.; Vansteelandt, M.; Marti, G.; Nasri, I.; Racaud-Sultan, C.; Fabre, N. Cucurbitacins from the Leaves of Citrullus colocynthis (L.) Schrad. Molecules 2015, 20, 18001-18015.

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