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Molecules 2014, 19(9), 15314-15323;

Organic Nitrates: Past, Present and Future

Biotechnology Center, Federal University of Paraíba, João Pessoa, PB 58037-760, Brazil
Health Sciences Center, Federal University of Paraíba, João Pessoa, PB 58037-760, Brazil
Faculty of Pharmacy and Alternative Medicine, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan
Interdisciplinary Center for Biotechnology Research, Federal University of Pampa, Antônio Trilha Avenue, P.O. Box 1847, São Gabriel, RS 97300-000, Brazil
Authors to whom correspondence should be addressed.
Received: 7 July 2014 / Revised: 31 August 2014 / Accepted: 12 September 2014 / Published: 24 September 2014
(This article belongs to the Section Organic Chemistry)
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Nitric oxide (NO) is one of the most important vasodilator molecules produced by the endothelium. It has already been established that NO/cGMP signaling pathway deficiencies are involved in the pathophysiological mechanisms of many cardiovascular diseases. In this context, the development of NO-releasing drugs for therapeutic use appears to be an effective alternative to replace the deficient endogenous NO and mimic the role of this molecule in the body. Organic nitrates represent the oldest class of NO donors that have been clinically used. Considering that tolerance can occur when these drugs are applied chronically, the search for new compounds of this class with lower tolerance potential is increasing. Here, we briefly discuss the mechanisms involved in nitrate tolerance and highlight some achievements from our group in the development of new organic nitrates and their preclinical application in cardiovascular disorders. View Full-Text
Keywords: organics nitrates; nitrate tolerance; 1,3-dibutoxy-2-propyl nitrate organics nitrates; nitrate tolerance; 1,3-dibutoxy-2-propyl nitrate

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França-Silva, M.S.; Balarini, C.M.; Cruz, J.C.; Khan, B.A.; Rampelotto, P.H.; Braga, V.A. Organic Nitrates: Past, Present and Future. Molecules 2014, 19, 15314-15323.

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