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Molecules 2014, 19(9), 14999-15004;

A Novel Synthesis of the Oxazolidinone Antithrombotic Agent Rivaroxaban

Pharmacy College, Chongqing Medical University, Chongqing 400016, China
Author to whom correspondence should be addressed.
Received: 26 June 2014 / Revised: 9 September 2014 / Accepted: 9 September 2014 / Published: 18 September 2014
(This article belongs to the Section Organic Chemistry)
Full-Text   |   PDF [672 KB, uploaded 18 September 2014]   |  


A facile synthetic route of rivaroxaban has been developed. Using commercially available (R)-epichlorohydrin and bromobenzene as the starting materials, rivaroxaban was obtained in 39% overall yield using a Goldberg coupling as the key step. The synthetic route represents a convenient procedure for the production of rivaroxaban. View Full-Text
Keywords: rivaroxaban; oxazolidinone; Goldberg coupling reaction rivaroxaban; oxazolidinone; Goldberg coupling reaction

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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Yuan, J.; Liu, K.; Li, L.; Yuan, Y.; Liu, X.; Li, Y. A Novel Synthesis of the Oxazolidinone Antithrombotic Agent Rivaroxaban. Molecules 2014, 19, 14999-15004.

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