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Open AccessReview

PM00104 (Zalypsis®): A Marine Derived Alkylating Agent

by 1,† and 2,*,†
University of Washington School of Medicine, 1959 NE Pacific St, Seattle, WA 98195, USA
Fred Hutchinson Cancer Research Center, University of Washington, 825 Eastlake Avenue East, G-3630, Seattle, WA 98109-1023, USA
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Molecules 2014, 19(8), 12328-12335;
Received: 25 July 2014 / Revised: 11 August 2014 / Accepted: 11 August 2014 / Published: 15 August 2014
(This article belongs to the Special Issue Alkaloids: Novel Therapeutic Perspectives)
PM00104 (Zalypsis®) is a synthethic tetrahydroisoquinolone alkaloid, which is structurally similar to many marine organisms. The compound has been proposed as a potential chemotherapeutic agent in the treatment of solid human tumors and hematological malignancies. PM00104 is a DNA binding agent, causing inhibition of the cell cycle and transcription, which can lead to double stranded DNA breaks. After rigorous pre-clinical testing, the drug has been evaluated in a number of phase II clinical trials. This manuscript provides a review of current trials and appraises the efficacy of PM00104 as a future cancer treatment. View Full-Text
Keywords: PM00104; Zalypsis; alkaloid; chemotherapy; cancer therapy PM00104; Zalypsis; alkaloid; chemotherapy; cancer therapy
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MDPI and ACS Style

Petek, B.J.; Jones, R.L. PM00104 (Zalypsis®): A Marine Derived Alkylating Agent. Molecules 2014, 19, 12328-12335.

AMA Style

Petek BJ, Jones RL. PM00104 (Zalypsis®): A Marine Derived Alkylating Agent. Molecules. 2014; 19(8):12328-12335.

Chicago/Turabian Style

Petek, Bradley J.; Jones, Robin L. 2014. "PM00104 (Zalypsis®): A Marine Derived Alkylating Agent" Molecules 19, no. 8: 12328-12335.

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