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Molecules 2014, 19(5), 5459-5469;

Synthesis and Isomerization of Some Novel Pyrazolopyrimidine and Pyrazolotriazolopyrimidine Derivatives

Photochemistry Department, National Research Center, Dokki, Cairo 1258943, Egypt
Chemistry Department, Faculty of Science and Human Studies, Shaqra University, Huraiymla 11961, Kingdom of Saudi Arabia
Chemistry Department, Faculty of Science, Hail University, Hail 81411, Kingdom of Saudi Arabia
Chemistry Department, Faculty of Education, Shaqra University, Afif 11921, Kingdom of Saudi Arabia
Food Science and Nutrition Department, College of Food Science and Agriculture, King Saud University, Riyadh 11564, Kingdom of Saudi Arabia
Author to whom correspondence should be addressed.
Received: 30 March 2014 / Revised: 16 April 2014 / Accepted: 17 April 2014 / Published: 25 April 2014
(This article belongs to the Section Organic Chemistry)
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4-Imino-1-p-tolyl-1,4-dihydropyrazolo[3,4-d]pyrimidin-5-ylamine (2) and (1-p-tolyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-hydrazine (3) were prepared starting from ethyl 4-cyano-1-p-tolyl-1H-pyrazol-5-ylimidoformate (1). The structure of compound 3 was confirmed through preparation of the pyrazole derivatives 4 and 5. Also, the synthesis and structural characterization of pyrazolo[4,3-e][1,2,4]triazolo[4,3-c]pyrimidine derivatives 7 and 9 and their isomerization to pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine derivatives 6 and 8, respectively, under different suitable reaction conditions were reported. Moreover, the syntheses of 2-substituted-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine derivatives 10 and 11 was described. View Full-Text
Keywords: pyrazoles; pyrazolopyrimidines; pyrazolotriazolopyrimidines; isomerization pyrazoles; pyrazolopyrimidines; pyrazolotriazolopyrimidines; isomerization

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Rashad, A.E.; Shamroukh, A.H.; Abdel-Megeid, R.E.; Ali, H.S. Synthesis and Isomerization of Some Novel Pyrazolopyrimidine and Pyrazolotriazolopyrimidine Derivatives. Molecules 2014, 19, 5459-5469.

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