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Molecules 2014, 19(4), 3940-3954;

Water Extract of Acer tegmentosum Reduces Bone Destruction by Inhibiting Osteoclast Differentiation and Function

KM-Based Herbal Drug Development Group, Korea Institute of Oriental Medicine, Daejeon 305-811, Korea
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Received: 8 January 2014 / Revised: 24 March 2014 / Accepted: 25 March 2014 / Published: 1 April 2014
(This article belongs to the Section Natural Products Chemistry)
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The stem of Acer tegmentosum has been widely used in Korea for the treatment of hepatic disorders. In this study, we investigated the bone protective effect of water extract of the stem of Acer tegmentosum (WEAT). We found that WEAT inhibits osteoclast differentiation induced by receptor activator of nuclear factor-κB ligand (RANKL), an essential cytokine for osteoclast differentiation. In osteoclast precursor cells, WEAT inhibited RANKL-induced activation of JNK, NF-κB, and cAMP response element-binding protein, leading to suppression of the induction of c-Fos and nuclear factor of activated T cells cytoplasmic 1, key transcription factors for osteoclast differentiation. In addition, WEAT inhibited bone resorbing activity of mature osteoclasts. Furthermore, the oral administration of WEAT reduced RANKL-induced bone resorption and trabecular bone loss in mice. Taken together, our study demonstrates that WEAT possesses a protective effect on bone destruction by inhibiting osteoclast differentiation and function. View Full-Text
Keywords: Acer tegmentosum; osteoclast; bone; RANKL Acer tegmentosum; osteoclast; bone; RANKL

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Ha, H.; Shim, K.-S.; Kim, T.; An, H.; Lee, C.-J.; Lee, K.J.; Ma, J.Y. Water Extract of Acer tegmentosum Reduces Bone Destruction by Inhibiting Osteoclast Differentiation and Function. Molecules 2014, 19, 3940-3954.

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