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Angelica sinensis Improves Exercise Performance and Protects against Physical Fatigue in Trained Mice

School of Nutrition and Health Sciences, Taipei Medical University, Taipei 11031, Taiwan
Graduate Institute of Sports Science, College of Exercise and Health Sciences, National Taiwan Sport University, Taoyuan 33301, Taiwan
National Laboratory Animal Center, National Applied Research Laboratories, Taipei 11529, Taiwan
Department of Sports Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
Author to whom correspondence should be addressed.
Molecules 2014, 19(4), 3926-3939;
Received: 9 February 2014 / Revised: 3 March 2014 / Accepted: 17 March 2014 / Published: 31 March 2014
(This article belongs to the Section Natural Products Chemistry)
PDF [894 KB, uploaded 18 June 2014]


Angelica sinensis (AS) is a well-known medicinal herb and food material with antioxidative and multifunctional pharmacological activities. However, we lack evidence of the effect of AS on exercise performance and physical fatigue. We aimed to evaluate the potential beneficial effect of AS on ergogenic and anti-fatigue functions after physiological challenge. Male ICR strain mice were randomly assigned to four groups (n = 10 per group) for treatment: (1) sedentary control and vehicle treatment (vehicle control); (2) exercise training with vehicle treatment (exercise control); (3) exercise training with AS treatment at 0.41 g/kg/day (Ex-AS1); and (4) 2.05 g/kg/day (Ex-AS5); both the vehicle and AS were orally administered for 6 weeks. Exercise performance and anti-fatigue function were evaluated by forelimb grip strength, exhaustive swimming time, and levels of serum lactate, ammonia, glucose, and creatine kinase (CK) after a 15-min swimming exercise. Trend analysis revealed that AS treatments significantly increased endurance swimming time and blood glucose level, and decreased serum lactate, ammonia and CK levels. Liver and muscle glycogen contents were higher for Ex-AS1 and Ex-AS5 groups than the exercise control. Therefore, AS supplementation improved exercise performance and had anti-fatigue properties in mice and may be an effective ergogenic aid in exercise training. View Full-Text
Keywords: Dong Quai; exhaustion; lactate; glycogen; exercise training Dong Quai; exhaustion; lactate; glycogen; exercise training

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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Yeh, T.-S.; Huang, C.-C.; Chuang, H.-L.; Hsu, M.-C. Angelica sinensis Improves Exercise Performance and Protects against Physical Fatigue in Trained Mice. Molecules 2014, 19, 3926-3939.

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