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Open AccessArticle

Total Synthesis and Anti-Viral Activities of an Extract of Radix isatidis

1
School of Pharmacy, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing 210023, China
2
The Second Hospital of Nanjing, 1-1 ZhongFu Road, Nanjing 210003, China
*
Authors to whom correspondence should be addressed.
Molecules 2014, 19(12), 20906-20912; https://doi.org/10.3390/molecules191220906
Received: 12 November 2014 / Revised: 7 December 2014 / Accepted: 9 December 2014 / Published: 12 December 2014
(This article belongs to the Section Medicinal Chemistry)
Radix isatidis (Banlangen), a famous traditional Chinese medicine, has been used for thousands of years in China due to its anti-viral activity. Through our research, we inferred that the anti-viral activity of Radix isatidis depended on the water-soluble part. Among the components of this extract, the isoquinoline derivative 1 was isolated for the first time and has shown better anti-viral activity than other constituents. In this study, to solve the problem of sourcing sufficient quantities of compound 1, a total synthesis route is described, and several analogues are also evaluated for their anti-viral activities. Among them, compound 8 shown potent anti-viral activity with an IC50 value of 15.3 µg/mL. The results suggested that isoquinoline derivatives possessed potent anti-viral activity and are worthy further development. View Full-Text
Keywords: Radix isatidis; isoquinoline derivative; anti-viral activity Radix isatidis; isoquinoline derivative; anti-viral activity
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MDPI and ACS Style

He, L.-W.; Liu, H.-Q.; Chen, Y.-Q.; Yang, J.-Y.; Wang, T.-L.; Li, W. Total Synthesis and Anti-Viral Activities of an Extract of Radix isatidis. Molecules 2014, 19, 20906-20912.

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