Total Synthesis and Anti-Viral Activities of an Extract of Radix isatidis
AbstractRadix isatidis (Banlangen), a famous traditional Chinese medicine, has been used for thousands of years in China due to its anti-viral activity. Through our research, we inferred that the anti-viral activity of Radix isatidis depended on the water-soluble part. Among the components of this extract, the isoquinoline derivative 1 was isolated for the first time and has shown better anti-viral activity than other constituents. In this study, to solve the problem of sourcing sufficient quantities of compound 1, a total synthesis route is described, and several analogues are also evaluated for their anti-viral activities. Among them, compound 8 shown potent anti-viral activity with an IC50 value of 15.3 µg/mL. The results suggested that isoquinoline derivatives possessed potent anti-viral activity and are worthy further development. View Full-Text
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He, L.-W.; Liu, H.-Q.; Chen, Y.-Q.; Yang, J.-Y.; Wang, T.-L.; Li, W. Total Synthesis and Anti-Viral Activities of an Extract of Radix isatidis. Molecules 2014, 19, 20906-20912.
He L-W, Liu H-Q, Chen Y-Q, Yang J-Y, Wang T-L, Li W. Total Synthesis and Anti-Viral Activities of an Extract of Radix isatidis. Molecules. 2014; 19(12):20906-20912.Chicago/Turabian Style
He, Li-Wei; Liu, Hua-Qing; Chen, Yu-Qing; Yang, Jing-Yan; Wang, Tian-Lin; Li, Wei. 2014. "Total Synthesis and Anti-Viral Activities of an Extract of Radix isatidis." Molecules 19, no. 12: 20906-20912.