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Open AccessCommunication

Saikosaponin D Isolated from Bupleurum falcatum Inhibits Selectin-Mediated Cell Adhesion

1
Enviromental Agriculture Research Division, Gyeonggido Agricultural Reaearch and Extension Services(GARES), Hwaseong, Gyeonggi-do 445-784, Korea
2
Bioindustial Process Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Jeongeup-si, Jeollabuk-do 580-185, Korea
3
LINC project group, University Industry Cooperation, Daejeon University, Daejeon 300-716, Korea
4
Department of Plant Resources, Kongju National University, Yesan 340-702, Korea
5
Department of Beauty Science, Kwangju Women's University, Gwangju 506-713, Korea
6
Department of Chemistry, Mokwon University, Daejeon 302-729, Korea
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Molecules 2014, 19(12), 20340-20349; https://doi.org/10.3390/molecules191220340
Received: 6 November 2014 / Revised: 2 December 2014 / Accepted: 2 December 2014 / Published: 4 December 2014
(This article belongs to the Collection Bioactive Compounds)
Three saikosaponins were isolated from the MeOH extract of the roots of Bupleurum falcatum L.: saikosaponins B3 (1); B4 (2); and D (3). Of the three, compound 3 inhibited the interaction of selectins (E, L, and P) and THP-1 cells with IC50 values of 1.8, 3.0 and 4.3 µM, respectively. Also, the aglycone structure 4 of compound 3 showed moderate inhibitory activity on L-selectin-mediated cell adhesion. From these results, we suspect that compound 3 isolated from Bupleurum falcatum roots would be a good candidate for therapeutic strategies to treat inflammation. View Full-Text
Keywords: Bupleurum falcatum L.; triterpenoid saponin; saikosaponin; selectin; cell adhesion molecules; anti-inflammatory agents Bupleurum falcatum L.; triterpenoid saponin; saikosaponin; selectin; cell adhesion molecules; anti-inflammatory agents
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Jang, M.-J.; Kim, Y.S.; Bae, E.Y.; Oh, T.-S.; Choi, H.-J.; Lee, J.-H.; Oh, H.-M.; Lee, S.W. Saikosaponin D Isolated from Bupleurum falcatum Inhibits Selectin-Mediated Cell Adhesion. Molecules 2014, 19, 20340-20349.

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