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Optimization of Supercritical Fluid Extraction of Oil from the Fruit of Gardenia jasminoides and Its Antidepressant Activity

by Weiwei Tao 1,2,3, Hailou Zhang 1,2, Wenda Xue 1,2, Li Ren 1,2, Baomei Xia 1,2, Xin Zhou 1,2, Haoxin Wu 1,2, Jinao Duan 3 and Gang Chen 1,2,*
1
Center for Translational Systems Biology and Neuroscience, School of Basic Biomedical Science, Nanjing University of Chinese Medicine, Nanjing 210023, China
2
Laboratory of Integrative Biomedicine of Brain Diseases, School of Basic Biomedical Science, Nanjing University of Chinese Medicine, Nanjing 210023, China
3
National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China
*
Author to whom correspondence should be addressed.
Molecules 2014, 19(12), 19350-19360; https://doi.org/10.3390/molecules191219350
Received: 29 September 2014 / Revised: 6 November 2014 / Accepted: 13 November 2014 / Published: 25 November 2014
A response surface methodology was applied to optimize the variables affecting the supercritical fluid carbon dioxide extraction of oil from the fruit of Gardenia jasminoides using the Box–Behnken design. The optimum extraction parameters were an extraction temperature of 49.94 °C, an extraction pressure of 29.89 MPa and an extraction time of 93.82 min. Through a GC/MS analysis, we revealed 16 major components of the oil extract, which showed potent antidepressant effects in both of two behavior despair models in mice: tail suspension test and forced swimming test. Our results suggest that the oil extract of Gardenia jasminoides prepared using the supercritical fluid carbon dioxide extraction may contain effective constituents to be used for depression therapy. View Full-Text
Keywords: supercritical fluid extraction; response surface methodology; oil; Gardenia jasminoides; antidepressant effect supercritical fluid extraction; response surface methodology; oil; Gardenia jasminoides; antidepressant effect
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Tao, W.; Zhang, H.; Xue, W.; Ren, L.; Xia, B.; Zhou, X.; Wu, H.; Duan, J.; Chen, G. Optimization of Supercritical Fluid Extraction of Oil from the Fruit of Gardenia jasminoides and Its Antidepressant Activity. Molecules 2014, 19, 19350-19360.

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