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Article

Antifungal Compounds Produced by Colletotrichum gloeosporioides, an Endophytic Fungus from Michelia champaca

by
Vanessa Mara Chapla
1,†,
Maria Luiza Zeraik
1,†,
Ioanis Hcristos Leptokarydis
1,†,
Geraldo Humberto Silva
2,
Vanderlan Silva Bolzani
1,
Maria Claudia M. Young
3,
Ludwig Heinrich Pfenning
4 and
Angela Regina Araújo
1,*
1
NuBBE - Núcleo de Bioensaios, Biossíntese e Ecofisiologia de Produtos Naturais, Departamento de Química Orgânica, Instituto de Química, UNESP, Universidade Estadual Paulista, Araraquara-SP 14800-900, Brazil
2
Instituto de Ciências Exatas, Universidade Federal de Viçosa, Viçosa, MG, 38810-000, Brazil
3
Instituto de Botânica, Núcleo de Pesquisa em Fisiologia e Bioquímica, São Paulo-SP, 04301-902, Brazil
4
Departamento de Fitopatologia, Universidade Federal de Lavras, Lavras, MG, 37200-000, Brazil
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Molecules 2014, 19(11), 19243-19252; https://doi.org/10.3390/molecules191119243
Submission received: 8 October 2014 / Revised: 14 November 2014 / Accepted: 14 November 2014 / Published: 21 November 2014
(This article belongs to the Section Natural Products Chemistry)
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Abstract

In this study, eight endophytic fungi were isolated from the leaves, stems and roots of Michelia champaca. The isolates were screened and evaluated for their antifungal, anticancer and acetylcholinesterase (AChE) inhibitory activities. All of the extracts exhibited potent activity against two evaluated phytopathogenic fungi. Chemical investigation of EtOAc extracts of the endophytic fungus Colletotrichum gloeosporioides resulted in the isolation of one new compound, 2-phenylethyl 1H-indol-3-yl-acetate (1), and seven known compounds: uracil (2), cyclo-(S*-Pro-S*-Tyr) (3), cyclo-(S*-Pro-S*-Val) (4), 2(2-aminophenyl)acetic acid (5), 2(4-hydroxyphenyl)acetic acid (6), 4-hydroxy- benzamide (7) and 2(2-hydroxyphenyl)acetic acid (8). All of the compound structures were elucidated using 1D and 2D NMR and MS analyses. The antifungal and AChE inhibitory activities of compounds 1–8 were evaluated in vitro. Compound 1 exhibited promising activity against Cladosporium cladosporioides and C. sphaerospermum that was comparable to that of the positive control nystatin.
Keywords: Colletotrichum gloeosporioides; endophytic fungus; antifungal activity Colletotrichum gloeosporioides; endophytic fungus; antifungal activity
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MDPI and ACS Style

Chapla, V.M.; Zeraik, M.L.; Leptokarydis, I.H.; Silva, G.H.; Bolzani, V.S.; Young, M.C.M.; Pfenning, L.H.; Araújo, A.R. Antifungal Compounds Produced by Colletotrichum gloeosporioides, an Endophytic Fungus from Michelia champaca. Molecules 2014, 19, 19243-19252. https://doi.org/10.3390/molecules191119243

AMA Style

Chapla VM, Zeraik ML, Leptokarydis IH, Silva GH, Bolzani VS, Young MCM, Pfenning LH, Araújo AR. Antifungal Compounds Produced by Colletotrichum gloeosporioides, an Endophytic Fungus from Michelia champaca. Molecules. 2014; 19(11):19243-19252. https://doi.org/10.3390/molecules191119243

Chicago/Turabian Style

Chapla, Vanessa Mara, Maria Luiza Zeraik, Ioanis Hcristos Leptokarydis, Geraldo Humberto Silva, Vanderlan Silva Bolzani, Maria Claudia M. Young, Ludwig Heinrich Pfenning, and Angela Regina Araújo. 2014. "Antifungal Compounds Produced by Colletotrichum gloeosporioides, an Endophytic Fungus from Michelia champaca" Molecules 19, no. 11: 19243-19252. https://doi.org/10.3390/molecules191119243

APA Style

Chapla, V. M., Zeraik, M. L., Leptokarydis, I. H., Silva, G. H., Bolzani, V. S., Young, M. C. M., Pfenning, L. H., & Araújo, A. R. (2014). Antifungal Compounds Produced by Colletotrichum gloeosporioides, an Endophytic Fungus from Michelia champaca. Molecules, 19(11), 19243-19252. https://doi.org/10.3390/molecules191119243

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