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Molecules 2014, 19(11), 18966-18979;

The Diterpenes Ovoideal A–G from Tirpitzia ovoidea

Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University Health Science Center, Xueyuan Road, Beijing 100191, China
Author to whom correspondence should be addressed.
Received: 23 September 2014 / Revised: 4 November 2014 / Accepted: 5 November 2014 / Published: 18 November 2014
(This article belongs to the Section Medicinal Chemistry)
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Seven new diterpenes, named ovoideal A (1), B (2), C (3), D (4), E (5), F (6) and G (7), have been isolated along with eleven known diterpenes 818 from the petroleum ether soluble fraction of an ethanol extract of the aerial parts of Tirpitzia ovoidea. The structures of the new compounds were elucidated primarily by 1D and 2D NMR spectroscopy, as well as by the HR-ESI-MS spectrometry. All compounds were isolated from the Linaceae family for the first time. The in vitro cytotoxic activity of compounds 1, 35, 818 was evaluated against the Hela, HepG2 and K562 cell lines. Among them, compounds 3, 9, 11, 12, 13, 14, 15, 17, 18 showed moderate inhibitory activities. View Full-Text
Keywords: Tirpitzia ovoidea; Linaceae; diterpene; cytotoxic activity Tirpitzia ovoidea; Linaceae; diterpene; cytotoxic activity

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Su, D.; Yang, X.-Y.; Feng, X.; Shang, M.-Y.; Cai, S.-Q. The Diterpenes Ovoideal A–G from Tirpitzia ovoidea. Molecules 2014, 19, 18966-18979.

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