Molecules 2014, 19(10), 16013-16023; https://doi.org/10.3390/molecules191016013
Ethanolic Extract of Taheebo Attenuates Increase in Body Weight and Fatty Liver in Mice Fed a High-Fat Diet
1
Research Group of Nutrition and Metabolic System, Korea Food Research Institute, Seongnam 463-746, Korea
2
Division of Food Biotechnology, University of Science and Technology, Daejeon 305-350, Korea
3
Erom Life Science Corporation Corporation/R&D Center, Seongnam 443-702, Korea
*
Author to whom correspondence should be addressed.
Received: 2 September 2014 / Revised: 26 September 2014 / Accepted: 29 September 2014 / Published: 8 October 2014
(This article belongs to the Section Natural Products Chemistry)
Abstract
We evaluated whether intake of an ethanolic extract of Taheebo (TBE) from Tabebuia avellanedae protects against body weight increase and fat accumulation in mice with high-fat diet (HFD)-induced obesity. Four-week old male C57BL/6 mice were fed a HFD (25% fat, w/w) for 11 weeks. The diet of control (HFD) mice was supplemented with vehicle (0.5% sodium carboxymethyl cellulose by gavage); the diet of experimental (TBE) mice was supplemented with TBE (150 mg/kg body weight/day by gavage). Mice administered TBE had significantly reduced body weight gain, fat accumulation in the liver, and fat pad weight, compared to HFD mice. Reduced hypertrophy of fat cells was also observed in TBE mice. Mice administered TBE also showed significantly lower serum levels of triglycerides, insulin, and leptin. Lipid profiles and levels of mRNAs and proteins related to lipid metabolism were determined in liver and white adipose tissue of the mice. Expression of mRNA and proteins related to lipogenesis were decreased in TBE-administered mice compared to mice fed HFD alone. These results suggest that TBE inhibits obesity and fat accumulation by regulation of gene expression related to lipid metabolism in HFD-induced obesity in mice. View Full-TextKeywords:
Taheebo; Tabebuia avellanedae; obesity; lipid metabolism
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Choi, W.H.; Um, M.Y.; Ahn, J.; Jung, C.H.; Park, M.K.; Ha, T.Y. Ethanolic Extract of Taheebo Attenuates Increase in Body Weight and Fatty Liver in Mice Fed a High-Fat Diet. Molecules 2014, 19, 16013-16023.
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