Antibacterial and Antioxidant Activities of Ursolic Acid and Derivatives
by
Patrícia G.G. Do Nascimento 1, Telma L.G. Lemos 1,*, Ayla M.C. Bizerra 1, Ângela M.C. Arriaga 1, Daniele A. Ferreira 1, Gilvandete M.P. Santiago 2, Raimundo Braz-Filho 3 and José Galberto M. Costa 4
Patrícia G.G. Do Nascimento 1, Telma L.G. Lemos 1,*, Ayla M.C. Bizerra 1, Ângela M.C. Arriaga 1, Daniele A. Ferreira 1, Gilvandete M.P. Santiago 2, Raimundo Braz-Filho 3 and José Galberto M. Costa 4
1
Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, Fortaleza-CE 60451-970, Brazil
2
Departamento de Farmácia, Universidade Federal do Ceará, Fortaleza-CE 60430-370, Brazil
3
Laboratório de Ciências Químicas (LCQUI)-CCT-UENF/PPGQO-DEQUIM-UFRRJ, Campos dos Goytacazes-RJ 28013-602, Brazil
4
Laboratório de Pesquisa de Produtos Naturais, Universidade Regional do Cariri, Crato-CE 63105-000, Brazil
*
Author to whom correspondence should be addressed.
Molecules 2014, 19(1), 1317-1327; https://doi.org/10.3390/molecules19011317
Received: 7 November 2013 / Revised: 11 December 2013 / Accepted: 20 December 2013 / Published: 21 January 2014
Ursolic acid, an important bioactive compound, was isolated from ethanol extract of aerial parts of Sambucus australis. In order to develop bioactive ursolic acid derivatives, two semi-synthetic compounds were obtained through modification at C-3. The antibacterial activity of the ursolic acid and its derivatives was investigated. The microdilution method was used for determination of the minimal inhibitory concentration (MIC), against twelve bacterial strains. The influence of ursolic acid and its derivatives on the susceptibility of some bacterial pathogens to the aminoglycosides antibiotics neomycin, amikacin, kanamycin and gentamicin was evaluated. The most representative synergistic effect was observed by 3β-formyloxy-urs-12-en-28-oic acid at the concentration of 64 μg/mL in combination with kanamycin against Escherichia coli (27), a multidrug-resistant clinical isolate from sputum, with reduction of MIC value from 128 μg/mL to 8 μg/mL. Ursolic acid and its derivatives were examined for their radical scavenger activity using the DPPH assay, and showed significant activity.
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MDPI and ACS Style
Do Nascimento, P.G.; Lemos, T.L.; Bizerra, A.M.; Arriaga, Â.M.; Ferreira, D.A.; Santiago, G.M.; Braz-Filho, R.; Costa, J.G.M. Antibacterial and Antioxidant Activities of Ursolic Acid and Derivatives. Molecules 2014, 19, 1317-1327.
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